Journal List > J Rheum Dis > v.22(3) > 1064186

Jang, Kim, Kim, Lee, Yoo, Lee, Chae, Han, Joo, and Ahn: A Case of Sweet's Syndrome Diagnosed Concomitantly with Sjögren's Syndrome

Abstract

Sweet's syndrome is an uncommon reactive dermatoses characterized by fever, polymorphonuclear leukocytosis, painful erythematous plaques, and dense dermal infiltrate of neutrophils. Sweet's syndrome can be associated with several diseases, including infectious diseases, malignant tumors, and autoimmune diseases. However, no case of Sweet's syndrome associated with Sjögren's syndrome (SjS) has been reported in Korea. A 44-year-old woman presented with acute pustular rashes and fever. The patient had multiple papulopustular skin rashes, and complained of fever, chills, and headache. Our patient had the characteristic clinical and histopathological features of Sweet's syndrome, in association with SjS, diagnosed by salivary gland scan, positive anti-SS-A/SS-B antibody, and sicca symptoms simultaneously. Thus, we report on a case of a patient with Sweet's syndrome with concomitant diagnosis of SjS.

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Figure 1.
Erythematous papulopustular rash over face (A), neck (B), left forearm (C), and right auricle (D).
jrd-22-175f1.tif
Figure 2.
(A) Diffuse swelling and perimuscular inflammatory infiltration of the left psoas muscle. (B) After treatment of Sweet's syndrome, significant remission of swelling and perimuscular inflammatory infiltration has occurred.
jrd-22-175f2.tif
Figure 3.
The salivary gland scan shows decreased uptake and delayed washout of the radiotracer by both parotid glands and both submandibular glands. This finding suggests primary Sjögren's syndrome. ANT: anterior view, LAT: lateral view, LT: left, RT: right, PG: parotid gland, EF: ejection fraction, SMG: submandibular gland.
jrd-22-175f3.tif
Figure 4.
(A) The epidermis desquamated and diffuse infiltration of inflammatory cells in deep dermis (H&E, ×40). (B) An infiltration of predominantly neutrophils, without evidence of vasculitis (H&E, ×400).
jrd-22-175f4.tif
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