Journal List > J Rheum Dis > v.21(2) > 1064167

Son, Lee, Kim, Joo, Lee, Song, Kim, Tae, Yoo, and Jun: A Case of Calcium Pyrophosphate Dihydrate Deposition Disease Associated with Primary Hyperparathyroidism

Abstract

Calcium pyrophosphate dihydrate (CPPD) deposition disease is a heterogeneous group of diseases with CPPD crystal deposition. Aging is the most common risk factor for CPPD deposition, followed by osteoarthritis and previous injury. Occasionally, CPPD depositions are associated with familial predisposition and metabolic diseases, including hemo-chromatosis, primary hyperparathyroidism, hypophospha-tasia, and hypomagnesemia. CPPD deposition diseases associated with primary hyperparathyroidism in Koreans have rarely been reported. Thus, we report a case of a relatively young female patient with CPPD deposition disease associated with primary hyperparathyroidism, which was diagnosed through a polarized microscopic examination of the synovial fluid and a subtotal parathyroidectomy.

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Figure 1.
Linear calcifications are seen within the medial and lateral joint space of both knees (A) and the hip joints (B).
jrd-21-82f1.tif
Figure 2.
Parathyroid specimen shows chief cell hyperplasia of parathyroid gland (H&E, ×200).
jrd-21-82f2.tif
Figure 3.
The graph shows the change of serum calcium level and parathyroid hormone level following parathyroidectomy (normal range: 8.4∼10.4 mg/dL, 15∼65 pg/mL, respectively). pre OP: pre-operation.
jrd-21-82f3.tif
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