Journal List > J Rheum Dis > v.21(2) > 1064163

J Rheum Dis. 2014 Apr;21(2):54-63. Korean.
Published online April 30, 2014.  https://doi.org/10.4078/jrd.2014.21.2.54
Copyright © 2014 by The Korean College of Rheumatology
The Present and Future of Clinical Research for Korean Lupus Patients
Dam Kim, Soo-Kyung Cho and Yoon-Kyoung Sung
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Corresponding to: Yoon-Kyoung Sung, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Wangsimni-ro, Seongdong-gu, Seoul 133-792, Korea. Email: sungyk@hanyang.ac.kr
Received April 09, 2014; Revised April 24, 2014; Accepted April 25, 2014.

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Systemic lupus erythematosus (SLE) is considered to be the prototype of systemic autoimmune disease because it involves the most immune cells and it can affect all organs of the human body. Despite the advances in understanding the etiology and pathogenesis of SLE, a sobering fact is that only a few drugs have been licensed for its treatment. This may be associated with the difficulties in performing clinical trials due to its diverse clinical manifestations and comorbidities of SLE, as well as difficulties in determining the disease outcome. To determine the natural course and drug response of SLE patients, various observational studies have been conducted in Western countries. However, in Korea, sufficiently powered prospective clinical studies are scarce. In this review, we conducted a systematic review to be aware of the current status of clinical studies in Korean SLE patients. Identifying the topics for clinical studies that have been performed helps determine how the clinical research should be conducted for Korean SLE patients.

Keywords: Lupus erythematosus; Systemic; Clinical study; Korean

Figures


Figure 1
Selection of studies included in this review of systemic lupus erythematosus clinical researches.
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Tables


Table 1
Summary of the studies about lupus nephritis clinical researches in Korea
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Table 2
Summary of the studies about lupus outcome clinical researches in Korea
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Table 3
Summary of the studies about lupus comorbidity clinical researches in Korea
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