This article has been corrected. See "Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis" in Volume 21 on page 278.
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Abstract
Objective
The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles.
Methods
One hundred and nineteen Korean juvenile rheumatoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls.
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Table 1.
Number, median age at onset, percentage female for each of the JRA subgroup
| Type | Number (%) | Median age (range) | Sex: no. of female (%) |
|---|---|---|---|
| All JRA | 119 (42%) | 6.6 (0.6∼15.7) | 64 (53.8%) |
| Polyarticular | 50 | 7.8 (1.9∼15) | 32 (64%) |
| RF* + | 12 | 7.8 (4.1∼13.8) | 10 (83.3%) |
| RF* – | 38 | 7.8 (1.9∼15) | 22 (57.9%) |
| Pauciarticular | 35 (29.4%) | 6.8 (0.8∼15.7) | 16 (45.7%) |
| Systemic | 34 (28.6%) | 5.7 (0.6∼13.8) | 19 (44.2%) |
Table 2.
HLA-DRB1 phenotype frequencies in JRA patients, subtypes and controls
Table 3.
HLA-DRB1*01 phenotype frequency percentage and Odds ratio in each subtypes of JRA versus controls
| Subtypes | JRA* | Controls† | Odds ratio | p-value‡ | 95% C.I.§ |
|---|---|---|---|---|---|
| Polyarticular | 18.1% | 2.98 | ＜0.0001 | 1.66, 5.34 | |
| RF+ | 22.7% | 3.97 | 0.017∥ | 1.42, 11.10 | |
| RF− | 16.7% | 6.9% | 2.70 | 0.003 | 1.38, 5.26 |
| Pauciarticular | 21.7% | 3.75 | ＜0.0001 | 2.00, 7.00 |
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