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Kim, Lee, Lee, Lim, Kim, Park, and Lee: A Case of Secondary Gout Associated with Essential Thrombocythemia
Case Report
Journal of Rheumatic Diseases

Journal of Rheumatic Diseases 2012; 19(1): 47-50.

Published online: 28 February 2012

DOI: https://doi.org/10.4078/jrd.2012.19.1.47

A Case of Secondary Gout Associated with Essential Thrombocythemia

Young Min Kim, Sora Lee, Ji Eun Lee, Do Hyoung Lim, Il Kim, Keon Woo Park, Soon Il Lee

Department of Internal Medicine, Dankook University Medical College, Cheonan, Korea.

Corresponding author (avnrt@hanmail.net)

Received 14 July 2011       Revised 11 August 2011       Accepted 12 August 2011

Copyright © 2012 Korean College of Rheumatology

Abstract

Gouty arthritis is a metabolic disorder characterized by hyperuricemia, deposition of monosodium urate crystal in the joints, and recurrent episodes of acute inflammatory arthritis. Depending on the actual causes of hyperuricemia, gout is classified as primary or secondary gout. In myeloproliferative neoplasms, a turnover of nucleic acids is greatly augmented and therefore the blood concentration of uric acid may be markedly increased. But an acute attack of gout is extremely rare in patients with myeloproliferative neoplasms. Essential thrombocythemia, one of the myeloproliferative neoplasms, is characterized by megakaryocytic hyperplasia in bone marrow and marked thrombocytosis. We report a case of secondary gout in a 66-year-old man with essential thrombocythemia.

Keywords: Secondary gout, Essential thrombocythemia, Myeloproliferative neoplasm

Figures and Tables

Figure 1
The peripheral blood smear shows leukoerythroblastosis and increased numbers of platelets.
jrd-19-47-g001
Figure 2
Microscopically, (A) the bone marrow shows hypercellular marrow with fibrosis (H&E, ×100) and (B) megakaryocytic hyperplasia with frequent distorted forms (H&E, ×400).
jrd-19-47-g002

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