Journal List > J Rheum Dis > v.19(2) > 1063955

J Rheum Dis. 2012 Apr;19(2):104-107. Korean.
Published online April 30, 2012.  https://doi.org/10.4078/jrd.2012.19.2.104
Copyright © 2012 by The Korean College of Rheumatology
A Cases of Adult Onset Still's Disease with Hemolytic Anemia
Jin Kyu Jung, Yong Jun Kim, Chang Kyoo Byon, Sang Yeob Lee, Sung Won Lee and Won Tae Chung
Department of Internal Medicine, College of Medicine, Dong-A University, Pusan, Korea.

Corresponding to: Won Tae Chung, Department of Internal Medicine, College of Medicine, Dong-A University, Dongdaesin-dong 3-ga, Seo-gu, Pusan 602-715, Korea. Email: wtchung@dau.ac.kr
Received August 08, 2011; Accepted August 30, 2011.

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology. AOSD is characterized by fever, arthralgia, salmon-colored skin rash, hepatosplenomegaly and its laboratory abnormalities include leukocytosis, elevated liver enzyme, negative autoantibody, and hyperferritinemia. The clinical course varied and severe complicated conditions, such as hemophagocytic syndrome, and disseminated intravascular coagulation, occurred occasionally. Such a complication is accompanied with hemolytic anemia and lead to be a fatal course. We report the first case of AOSD with hemolytic anemia, which improved with high dose steroid therapy.

Keywords: Adult onset still disease; Hemolytic anemia

Figures


Figure 1
Peripheral blood shows polychromasia and schistocytes (Wright-Giemsa stain, ×1,000).
Click for larger image


Figure 2
Bone marrow aspiration shows a slight increase in the number of myeloid precursors. The marrow is slightly hypocellular (Wright-Giemsa stain, ×200).
Click for larger image


Figure 3
Abdomen CT shows hepatosplenomegaly.
Click for larger image

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