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Yoo, Kim, Song, Kim, Kim, Jo, and Kang: Eosinophilic Fasciitis as the Initial Manifestation of Graft-Versus-Host Disease
Case

J Rheum Dis 2011;18(1):64-67.

Published online: 31 March 2011

DOI: https://doi.org/10.4078/jrd.2011.18.1.64

Eosinophilic Fasciitis as the Initial Manifestation of Graft-Versus-Host Disease

In Seol Yoo1, Min Kyung Kim1, Seung Tak Song1, Jin Hyun Kim1, Jin Man Kim2, Deog Yeon Jo1, Seong Wook Kang1

1Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea

2Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea

Received 6 October 201018 October 2010       Accepted 19 October 2010

Copyright © 2011 The Korean College of Rheumatology

Abstract

Eosinophilic fasciitis (EF) is a relatively rare disorder characterized by eosinophilia of the peripheral blood and inflammation of fascia and skin. The etiology of EF is un-known but it can precede or occur concomitantly with hematologic disorders including malignancy. EF can rarely occur after bone marrow transplantation and is a feature of chronic graft-versus-host disease (cGVHD). We report a 49-year-old man who developed EF as the first manifestation of cGVHD after allogeneic hematopoietic stem cell transplantation (AlloHSCT).

Keywords: Eosinophilic fasciitis, Graft-versus-host disease, Allogeneic hematopoietic stem cell transplantation

References

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Figure 1.
Induration and swelling of both forearm and wrist (arrow).
jrd-18-64f1.tif
Figure 2.
Forearm skin & muscle biopsy. Numerous eosinophils (arrow) and mononuclear cells were observed in fascia and muscle.
jrd-18-64f2.tif
Figure 3.
Buttock skin biopsy. Vacuolar degeneration of basal cells, dermal melanophages, sparse infiltration of perivascular mononuclear cell and eosinophils.
jrd-18-64f3.tif
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