Journal List > J Rheum Dis > v.18(1) > 1063946

Yoo, Kim, Song, Kim, Kim, Jo, and Kang: Eosinophilic Fasciitis as the Initial Manifestation of Graft-Versus-Host Disease

Abstract

Eosinophilic fasciitis (EF) is a relatively rare disorder characterized by eosinophilia of the peripheral blood and inflammation of fascia and skin. The etiology of EF is un-known but it can precede or occur concomitantly with hematologic disorders including malignancy. EF can rarely occur after bone marrow transplantation and is a feature of chronic graft-versus-host disease (cGVHD). We report a 49-year-old man who developed EF as the first manifestation of cGVHD after allogeneic hematopoietic stem cell transplantation (AlloHSCT).

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Figure 1.
Induration and swelling of both forearm and wrist (arrow).
jrd-18-64f1.tif
Figure 2.
Forearm skin & muscle biopsy. Numerous eosinophils (arrow) and mononuclear cells were observed in fascia and muscle.
jrd-18-64f2.tif
Figure 3.
Buttock skin biopsy. Vacuolar degeneration of basal cells, dermal melanophages, sparse infiltration of perivascular mononuclear cell and eosinophils.
jrd-18-64f3.tif
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