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Kim, Kim, Je, Park, Park, Kong, Kang, Ahn, Cha, Lim, Kim, Lee, Jang, and Hong: A Case of Multiple Endocrine Neoplasia Type 1 with Papillary Thyroid Carcinoma
Case Report
Journal of Korean Society of Endocrinology

Journal of Korean Society of Endocrinology 2006; 21(1): 79-84.

Published online: 20 February 2006

DOI: https://doi.org/10.3803/jkes.2006.21.1.79

A Case of Multiple Endocrine Neoplasia Type 1 with Papillary Thyroid Carcinoma

Hai Jin Kim, Chul Sik Kim, Hyun Chul Je, Jina Park, Jong Suk Park, Jee Hyun Kong, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Hang Suk Jang1, Soon Won Hong2

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

1Department of General Surgery, Yonsei University College of Medicine, Seoul, Korea.

2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Received 24 May 2005       Accepted 4 August 2005

Copyright © 2006 Korean Endocrine Society

Abstract

This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN 1). It is an hereditary syndrome characterized by neoplastic disorders such as pituitary adenoma, parathyroid adenoma or hyperplasia and pancreatic neuroendocrine tumor, such as gastrinoma just like in our case. But sometimes pheochromocytoma, mucosal ganglioneuromas, lipoma, forgut carcinoid and thyroid disease could be accompany the disease, but coincidental papillary thyroid carcinoma was never reported before in Korea. Herein we represent a 39-year-old woman who manifested typical features of MEN 1 with coincidental papillary thyroid carcinoma. Despite with definite family history of MEN 1, her genetic analysis of DNA had not found any germline mutation in MEN 1 gene. Unidentified culprit gene unable further genetic study of finding LOH (loss of heterogeneity) in 11q13, the possible explanation of papillary thyroid carcinoma as a new component of MEN 1. As we have experienced a case of MEN 1 combined with papillary thyroid carcinoma, we report it with the review of literature.

Keywords: MEN 1, Papillary thyroid carcinoma, Prolactinoma, Gastrinoma, Parathyroid hyperplasia

Figures and Tables

Fig. 1
Thyroid US shows about 1.5 cm irregular mass at upper pole of right thyroid gland.
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Fig. 2
Sellar MRI shows 9 × 6 mm sized microadenoma in left portion of pituitary gland.
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Fig. 3
Abdominal dynamic CT shows 6.8 mm sized arterial enhancing mass at pancreatic body.
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Fig. 4
Histologic feature of thyroid papillary carcinoma showing inclusion body (H & E stain, × 400).
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Fig. 5
Histologic feature of parathyroid hyperplasia (H & E stain, × 40).
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