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Song, Choi, You, Shin, Kim, Choi, Park, Kim, Chun, and Joh: A Case of Idiopathic Myelofibrosis Associated with Acromegaly Patient
Case Report
Journal of Korean Society of Endocrinology

Journal of Korean Society of Endocrinology 2006; 21(4): 328-332.

Published online: 20 August 2006

DOI: https://doi.org/10.3803/jkes.2006.21.4.328

A Case of Idiopathic Myelofibrosis Associated with Acromegaly Patient

Jun Young Song, Pyoung Rak Choi, Hong Jun You, Seong Hoon Shin, Yu Ri Kim, Young Sik Choi, Yo Han Park, Mi Hyang Kim1, Bong Kwon Chun2, Young Duk Joh3

Department of Internal Medicine, Kosin University College of Medicine, Korea.

1Department of Clinical Pathology, Kosin University College of Medicine, Korea.

2Department of Pathology, Kosin University College of Medicine, Korea.

3Department of Diagnostic Radiology, Kosin University College of Medicine, Korea.

Received 14 December 2005       Accepted 16 February 2006

Copyright © 2006 Korean Endocrine Society

Abstract

Acromegaly is a chronic condition resulting from the excessive secretion of growth hormone and insulin like growth factor 1, generally from pituitary adenoma. Although there have been several reports suggesting the possible association of hematologic malignancies with acromegaly, myelofibrosis with acromegaly is very rare. Here we report 54-year-old male patient with myelofibrosis accompanied with acromegaly. We treated this patient with low dose thalidomide (50 mg/day) and prednisone (30 mg/day). We reported this case with literature review.

Keywords: Acromegaly, Low dose thalidomide, Myelofibrosis

Figures and Tables

Fig. 1
Peripheral blood smear shows that erythrocytes are microcystic and hypochromic, with moderate anisopoikilocytosis such as ovalocytes, tear-drop cells, burr cells and schistocytes (Wright's stain, ×100).
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Fig. 2
Bone marrow reveals extensive loose fibrosis and several small clusters of myeloblasts, with remaining some erythropoietic cells. (H&E stain, ×400)
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Fig. 3
Foot X-ray shows the thickness of heel pad is over 30 mm.
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Fig. 4
Coronal T1WI (A) and T2WI (B) MR show a pituitary microadenoma with non-enhancing mass in the right side of sella. Note slight depression of floor (arrow) and displaced infundibulum. Sagittal T1WI (C) and enhanced image (D) shows intrapituitary lesion that enhance less than normal pituitary gland.
jkse-21-328-g004
Table 1
Changes of serum growth hormone (GH) concentrations by oral glucose loading
jkse-21-328-i001

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