Journal List > J Korean Soc Endocrinol > v.21(4) > 1063875

J Korean Soc Endocrinol. 2006 Aug;21(4):319-327. Korean.
Published online August 20, 2006.
Copyright © 2006 Korean Endocrine Society
The Relationship between the Leptin Concentration and the Small Dense Low Density Lipoprotein Cholesterol Concentration in Korean Type 2 Diabetic Patients
Wan Sub Shim,1 Hae Jin Kim,1 Eun Seok Kang,1,2 Yu Mie Rhee,1,2 Chul Woo Ahn,1,2 Sung Kil Lim,1,2 Hyun Chul Lee,1,2 and Bong Soo Cha1,2
1Department of Internal Medicine, Yonsei University College of Medicine, Korea.
2Department of Institute of Endocrine Research, Yonsei University College of Medicine, Korea.
Received December 26, 2005; Accepted June 04, 2006.



Leptin has been suggested as a possible cause of atherosclerotic disease. The small dense low-density lipoprotein cholesterol (LDL-C) has also been regarded as a new surrogate marker in atherosclerotic disease. The aim of this study was to evaluate the relationship between the leptin concentration and the small dense LDL-C concentration in Korean type 2 diabetic patients.


One hundred-ninety one type 2 diabetic patients, who did not use any medication that could affect the concentration of lipid such as statin, fibrate, thiazolidinediones and corticosteroid, were enrolled in this study. We analyzed the relationship between leptin, the small dense LDL-C and the other metabolic parameters.


The small dense LDL-C concentrations were higher in the group with the highest tertile of the leptin value, both in males and females than those patients in the group with the lowest tertile of the leptin value. The small dense LDL-C concentrations were also higher in the group with the highest tertile of leptin divided by the BMI value both in males and females than those patients in the group with the lowest tertile of the leptin value. The leptin concentration was positively correlated with the small dense LDL-C, total cholesterol, triglyceride, LDL-C, insulin and HOMAIR values after adjusting for age, gender and BMI.


The association between leptin and small dense LDL-C could be a factor that explains the association between leptin and cardiovascular disease.

Keywords: Leptin; Precipitation method; Small dense LDL; Type 2 diabetes mellitus


Table 1
Clinical characteristics of patients
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Table 2
Clinical characteristics according to the tertile of leptin in male
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Table 3
Clinical characteristics according to the tertile of leptin in female
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Table 4
Comparison of clinical characteristics of patients between with history of cardiovascular disease and without cardiovascular disease
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Table 5
Partial pearson's correlation with leptin (log) and other parameters after adjustment of age, sex and BMI
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