Journal List > J Korean Soc Endocrinol > v.20(1) > 1063836

Kim, Yoo, Kim, Chang, Yeon, and Shin: Two Cases of Apathetic Hyperthyroidism associated with Peripheral Eosinophilia


Peripheral eosinophilia is perpetually associated with many disease conditions like asthma, parasitic disease, IL-2 therapy, hypereosinophilic syndrome and eosinophilia/myalgia syndrome. Furthermore, peripheral eosinophilia may also be linked with Graves' disease, which is induced by thyroid-stimulating anti-TSH receptor antibodies and is related to type 2 helper T cell (Th2) predominant condition that is dependent on humoral immunity. In some of the cases of Graves' disease, thyrotoxicosis may induce peripheral eosinophilia associated with relative cortisol deficiency. In our present study, we present a case of two patients who were suffering from Graves' disease without any thyrotoxic symptoms and exhibited increased levels of peripheral eosinophil count. But, the count was observed to decreas in euthyroid state.

Figures and Tables

Fig. 1
Thyroid sonogram shows slightly enlarged both thyroid glands
Fig. 2
99mTc-O4 thyroid scan shows mild diffuse enlargement with increased uptake (case 1).
Fig. 3
Blood eosinophil counts are decreased after antithyroid drug medication (case 1)
Fig. 4
99mTc-O4 thyroid scan shows diffuse enlargement with increased uptake (case 2).
Fig. 5
Blood eosinophil counts are decreased after antithyroid drug medication (case 2).


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