Journal List > J Korean Soc Endocrinol > v.20(6) > 1063830

Kim: Osteoporosis and Vascular Calcification: Lesson from OPG KO Mice

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Table 1.
Regulators of RANKL, RANK, and OPG expression
Cell Type Molecule Stimulated by Inhibited by
OB/Stromal Cells OPG IL-1[32, 33], TNF-α[32,33], Vitamin D3[13, 34], IL-4[35], IL-13[35,36], BMP2[34], Emdogain[37], TGF-β[36,38], Testosterone[39], Estrogen[40], T3[41], Menaquinone-7[42], PGD2[43], IL-6[44], IL-11[45], Vasoactive intestinal peptide[46], Raloxifene[47], NO-donor[48], IL-18[49], Calcium[50], Oncostatin M[44], Leukemia inhibitory factor[44], LPS[51], IFN-γ[36], Bisphosphonates[52] PTH[13,38,53], PGE2[13,38,54], Vitamin A[55], TIEG1[56], IL-1[36,38,57], Glucocorticoid[58,59], IGF-1[60], Retinoids[61], Runx2[62], IL-6[36], IL-17[36], TNF-α[36], Cyclosporin A[63], Rapamycin[63], FK506[63]
RANKL Vitamin D3[13, 34], PTH[13,53], PGE2[13, 54], IL-1[32,36], TNF-α[32,36], IL-6[44], IL-11[13,36,45], IL-17[36], Calcium[50], Menaquinone-7[42], ROS[64], TIEG1[56], Histamine[65], Vitamin A[55], FGF2[66], Hyaluronan[67], Annexin II[68], Rolipram[69], Leukemia inhibitory factor[44], Oncostatin M[44], Glucocorticoid[58,59], Runx2[62], Cyclosporin A[63], Rapamycin[63], FK506[63], Adenosine triphosphate[70] Vasoactive intestinal peptide[46], IL-13[35], IFN-γ[36], PGD2[43], Estrogen[40], Vitamin K[71], IL-4[35], TGF-β[36,38], 3-Methylcholanthrene[72]
RANK Menaquinone-7[42] IL-4[35], IL-13[35], IL-6[44]
Monocytes/Macrophages Osteoclasts OPG Leptin[73] M-CSF[74]
RANKL CCR1 Chemokines[75] ND
RANK TGF-β[76], Vitamin D3[77], TPA[77], RANKL[78] Ascorbic acid[79], Heme-Oxygenase 1[80], TGF-β[81], IL-4[35], IL-13[35], OPG[82]
Endothelial Cells OPG IL-1[83,84], TNF-α[83,84], OPN/αγβ3[85,86] TGF-β[87]
RANKL IL-1[83,84], TNF-α[83,84], TGF-β[87], Indian hedgehog[88] ND
RANK VEGF[89] Osteostat/TNFSF18[90]
Vascular Smooth Muscle Cells OPG PDGF[91], bFGF[91], Angiotensin II[91], TNF-α[91], IL-1[91] PPAR-γ Ligand[92], Cyclosporin A[63], Insulin[93]
RANKL ND ND
RANK ND ND
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