Journal List > J Korean Soc Endocrinol > v.20(5) > 1063824

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Kang, Bae, Lee, Lim, Cho, Kim, and Song: A case of Methimazole-Induced Cholestatic Jaundice With Agranulocytosis
Case Report
Journal of Korean Society of Endocrinology

Journal of Korean Society of Endocrinology 2005; 20(5): 519-523.

Published online: 20 October 2005

DOI: https://doi.org/10.3803/jkes.2005.20.5.519

A case of Methimazole-Induced Cholestatic Jaundice With Agranulocytosis

Sang-Gu Kang, Jong-Oh Bae, Eun-Young Lee, Seong-Min Lim, Sang-Kun Cho, Ji-Hye Kim, Sun-Kyung Song

Division of Endocrinology and Metabolism, Department of Internal Medicine, Presbyterian Medical Center, Cheonju, Korea.

Received 4 August 2005       Accepted 10 October 2005

Copyright © 2005 Korean Endocrine Society

Abstract

Methimazole is a widely used and generally well-tolerated antithyroid agent. Adverse reactions occur in 1~5% of patients taking methimazole medication, but these are most commonly transient, benign leukopenia and a skin rash. Severe cholestatic jaundice, combined with agranulocytosis, has been known as a rare complication. Herein, a case of methimazole induced cholestatic jaundice, with agranulocytosis, is reported.

Keywords: Methimazole, Cholestatic jaundice, Agranulocytosis

Figures and Tables

Fig. 1
Abdominal Computed tomography showed unremarkable liver, gallbladder, pancreas, and spleen, without evidence of biliary dilatation.
jkse-20-519-g001
Fig. 2
Time course of white cell counts and body temperature in relation to treatment (G-CSF: Granulocyte-Colony Stimulating Factor, WBC: White Blood Cell, ANC:Absolute Granulocyte Count).
jkse-20-519-g002
Table 1
Serum Biochemical Changes before and after Discontinuation of Methimazole
jkse-20-519-i001

HD: Hospital day, TB: Total Bilirubin, DB: Direct Bilirubin, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, ALP: Alkaline phosphatase, γ-GT: Gamma glutamyltransferase, Free T4: Free Thyroxine, TSH: Thyroid-stimulating Hormone RI therapy: Radioiodine therapy

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