Journal List > J Korean Soc Endocrinol > v.20(3) > 1063793

J Korean Soc Endocrinol. 2005 Jun;20(3):294-298. Korean.
Published online June 30, 2005.
Copyright © 2005 Korean Endocrine Society
A Case of Hashimoto's Thyroiditis with Transient T3-Thyrotoxicosis Induced by Hydatidiform Mole
Ji Youn Yoo, Hong Ju Moon, Cheol Young Park, Seong Jin Lee, In Kyung Jeong, Eun Gyung Hong, Gi Weon Oh, Hyeon Kyu Kim, Doo Men Kim, Jae Myung Yoo, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Sung Woo Park and Soo Kee Min
Department of lnternal Medicine and Pathology, College of Medicine, Hallym University, Chunchon, Korea.
Received March 15, 2004; Accepted April 08, 2005.


Human chorionic gonadotropin (HCG) is a member of the glycoproteins family synthesized by the placenta, which consists of 2 noncovalently joined subunits (alpha(α) and beta(β)). The α- and β-subunits have a structural homology with the α- and β-subunits of TSH and LH. The thyrotropic action of HCG results from its structural similarity to TSH, so β-HCG can bind to the TSH receptor in the thyroid gland. A high level of HCG accompanied by an increased thyroid hormone level, can be observed in gestational trophoblastic disease (GTD), such as a hydatidiform mole or a choriocarcinoma, but the clinical symptoms of hyperthyroidism are rarely observed. We experienced a case of Hashimoto's thyroiditis, where the patient was diagnosed with T3-thyrotoxicosis, which had initially been induced by excess β-HCG due to an H-mole; after evacuation of the H-mole, the condition was diagnosed as hypothyroidism.

It has been speculated that a patient with Hashimoto's thyroiditis could have hyperthyroidism, induced by β-HCG, due to an H-mole.

Keywords: Hashimoto's thyroiditis; T3-thyrotoxicosis; Hyperthyroidism; GTD (Gestational trophoblastic disease); H-mole


Fig. 1
Pelvis MRI shows uterus enlargement (11×8×12 cm) and tiny cystic mass was filled in uterine cavity. The mass shows T1 low-T2 bright signal intensity and mesh-like enhancement.
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Fig. 2
Microscopic findings of endometrium shows hyperplastic trophoblasts on edematous enlarged villi (H&E, ×40)
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Fig. 3
Time course of serum thyroid hormone, TSH and β-HCG
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Fig. 4
Thyroid aspiration cytology shows some follicular cells showing small sized nuclei with smooth membrane and abundant cytoplasm. Many lymphocytes are scattered (Pap, ×200)
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