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Kang, Park, Kim, Lee, Hur, Han, Park, Kim, Ahn, Cha, Lim, Kim, and Lee: Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes
Original Article
Journal of Korean Society of Endocrinology

Journal of Korean Society of Endocrinology 2005; 20(1): 29-39.

Published online: 20 February 2005

DOI: https://doi.org/10.3803/jkes.2005.20.1.29

Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes

Eun Seok Kang, So Young Park, So Hun Kim, Hyun Joo Lee, Kyu Yeon Hur, Seung Jin Han, Se Eun Park, Hyeong Jin Kim1, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

1Department of Internal Medicine, Kwandong University College of Medicine, Gangneung, Korea.

Received 11 October 2004       Accepted 21 December 2004

Copyright © 2005 Korean Endocrine Society

Abstract

Background

The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene (ACDC) and the intima-media thickness (IMT) of the common carotid arteries in type 2 diabetic patients.

Methods

The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined.

Results

There was no significant difference in the carotid IMT among the SNP45 genotypes (0.66 ±0.18 mm for TT, 0.71±0.12 mm for TG and 0.64±0.15 mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype (3.35±2.00 µg/mL vs. 4.98±2.24 µg/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70±0.17 mm vs. 0.59±0.13 mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations (0.78±0.09 mm vs. 0.71±0.15 mm, P=0.013)

Conclusions

These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations.

Keywords: Adiponectin, ACDC, SNP, IMT (Intima-Media thickness), Type 2 diabetes

Figures and Tables

Table 1
The Allelic and Genotypic Distribution of SNP
jkse-20-29-i001
Table 2
Clinical and Biochemical Characteristics of the Subjects according to the Adiponectin Genotypes at Position 45
jkse-20-29-i002

Data are mean±SD

Table 3
Clinical and Biochemical Characteristics of the Subjects according to the Adiponectin Genotypes at Position 276
jkse-20-29-i003

Data are mean±SD

Table 4
Clinical Characteristics of the Subjects according to the Carrying Status of the Adiponectin 45/276 Genotype Combination
jkse-20-29-i004

Data are means±SD. P-values by t-test. *P value by chi-square test.

X represents either T or G

Table 5
Partial Correlation Coefficients Between the Log Mean IMT and the Variables (adjusted for age and body weight)
jkse-20-29-i005
Table 6
Association of Atherosclerotic Risk Factors with mean IMT of the Common Carotid Artery (multivariate linear regression ana lysis)
jkse-20-29-i006

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