Abstract
Background
The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene (ACDC) and the intima-media thickness (IMT) of the common carotid arteries in type 2 diabetic patients.
Methods
The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined.
Results
There was no significant difference in the carotid IMT among the SNP45 genotypes (0.66 ±0.18 mm for TT, 0.71±0.12 mm for TG and 0.64±0.15 mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype (3.35±2.00 µg/mL vs. 4.98±2.24 µg/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70±0.17 mm vs. 0.59±0.13 mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations (0.78±0.09 mm vs. 0.71±0.15 mm, P=0.013)
Figures and Tables
Table 2
Clinical and Biochemical Characteristics of the Subjects according to the Adiponectin Genotypes at Position 45
![jkse-20-29-i002](/upload/SynapseData/ArticleImage/1008jkse/jkse-20-29-i002.jpg)
Table 3
Clinical and Biochemical Characteristics of the Subjects according to the Adiponectin Genotypes at Position 276
![jkse-20-29-i003](/upload/SynapseData/ArticleImage/1008jkse/jkse-20-29-i003.jpg)
Table 4
Clinical Characteristics of the Subjects according to the Carrying Status of the Adiponectin 45/276 Genotype Combination
![jkse-20-29-i004](/upload/SynapseData/ArticleImage/1008jkse/jkse-20-29-i004.jpg)
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