Journal List > J Korean Soc Endocrinol > v.20(3) > 1063787

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Kong, Joo, Shin, Na, An, Kang, Park, Son, Kim, and Kim: A Case of Thyroid MALT Lymphoma without Autoimmune Thyroiditis
Case Report
Journal of Korean Society of Endocrinology

Journal of Korean Society of Endocrinology 2005; 20(3): 268-272.

Published online: 20 June 2005

DOI: https://doi.org/10.3803/jkes.2005.20.3.268

A Case of Thyroid MALT Lymphoma without Autoimmune Thyroiditis

Ok Nyu Kong, Sang-Hyen Joo, Sun Hye Shin, Min Ah Na, Jun Hyeop An, Yang Ho Kang, Do Youn Park1, Seok Man Son, In Ju Kim, Yong Ki Kim

Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea.

Department of Pathology1, College of Medicine, Pusan National University, Busan, Korea.

Received 10 December 2004       Accepted 10 March 2005

Copyright © 2005 Korean Endocrine Society

Abstract

A primary thyroid lymphoma is rare among all types of thyroid malignancy. Usually, a thyroid lymphoma is associated with underlying chronic autoimmune thyroiditis. Recently, we experienced a primary thyroid mucosa-associated lymphoid tissue (MALT) lymphoma, with an incidental micropapillary thyroid carcinoma, but lacking evidence of autoimmune thyroiditis. A female patient visited our hospital for further evaluation of a rapidly enlarging, painless thyroid mass which had been stable for 8 years. Lymphocytic thyroiditis or a lymphoma was suspected from fine needle aspiration performed at another hospital. The thyroid function test and other routine laboratory tests were normal. The histopathological findings after a total thyroidectomy revealed a MALT lymphoma with a micropapillary thyroid carcinoma. There was no evidence of chronic autoimmune thyroiditis. This is, to the best of our knowledge, the first case report of a MALT lymphoma arising from the thyroid gland without evidence of chronic autoimmune thyroiditis in Korea

Keywords: MALT lymphoma, Chronic autoimmune thyroiditis

Figures and Tables

Fig. 1
Computed tomography of the neck shows soft tissue mass in isthmus of thyroid gland (arrow)
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Fig. 2
Sections from thyroid gland showing proliferation of multiple lymphoid follicles with intervening thyroid follicular epithelial cells (H-E, ×40)
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Fig. 3
Atypical lymphoid cells infiltrating thyroid follicular cells, so-called lymphoepithelial lesions are seen (H-E, ×200)
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Fig. 4
Atypical lymphoid cells are positive for CD20 (IHC, ×200)
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Fig. 5
Sections from thyroid gland showing typical histologic features of papillary carcinoma (H-E, ×100)
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