This study was performed to evaluate the effect of 7-week comprehensive health promotion program for RA patients (CHPPRA) on changes in pain and depression. In addition, it was also examined that this effect was generated by changes in patients' health promoting strategies (positive self-image, positive thinking, problem solving, communication, pain management, stress management, exercise, and knowledge about RA) learned through CHPPRA. Twenty-eight out-patients of RA clinic in a university hospital participated for this study. The results are as followers. Changes in exercise, self-concept, positive thinking, problem solving, depression, and pain management were significant predictors to explain relieving pain level. Since all of these variables had positive standardized beta weights (betas), it can be interpreted that increasing level of these health promoting strategies may induce pain improvement. Changes in positive thinking, communication skill, exercise, self-concept, pain management, and knowledge about the disease were significant predictors to explain positive change in depression. Since all of the significant variables except the change in knowledge about the disease had positive standardized beta weights (betas), it can be interpreted that increasing level of these health promoting strategies may induce improving depression level. However, our results showed that the higher level of the knowledge about the disease was, the worse depression was.