This is a descriptive study on quality of life(QOL) and related factors of ostomates to provide a basic data for development of nursing interventions. The subjects were 110 ostomates who were members of the Daegu or Daejon branches of the Korean Ostomy Association. Data collection was performed between March 1st and April 6th, 1998. Measurements of QOL, self-care, family support, self-esteem, and hope were used as the study tools. Data were analyzed with the SAS program by using t-test, ANOVA, Pearson correlation and stepwise multiple regression. The results are as follows : 1) The score on the QOL scale ranged from 97 to 226 with a mean of 164.53(+/-28.29). 2) The score of QOL on the general and ostomate-related characteristic showed significant differences according to monthly income, monthly participation in ostomate meetings, combined treatments after operation, types of evacuation management, problems of ostomy, help in caring for the ostomy, length of time since ostomate surgery, and presence or absence of readmission after discharge. 3) There were significant positive correlations between quality in life and other factors ; self-esteem(r=0.7107, P<0.001), hope(r=0.6584, P<0.001) family support(r=0.6191, P<0.001), perception of health condition(r=0.6017, P<0.001), and self-care(r=0.2286, P<0.05). 4) The variables that affected the quality of life of the subjects were self-esteem, level of family support, perception of health condition, monthly participation in ostomate meetings, combined treatments after operation, monthly income, level of hope, and age in that order. The variance of quality of life was R2=77.20 percent by calculating the sum of those variables. In conclusion, it is necessary for nursing intervention to promote self-esteem, family support, and hope in the care of ostomates in order to improve QOL.