The purpose of this study was to identify the effect of the supportive nursing intervention program on Burden and Quality of Life in Mothers of Children with Nephrotic Sybdrome. The data were collected from a group of 67 mothers of nephrotic syndrome patients(34 in the intervention group, 33 in the control group) from July 1, 1998 to Dec, 30, 1988, Measurements were burden and quality of life from both groups at pre and post intervention. The supportive nursing educational program consists of individual lectures and discussion at the individual level. Listed are the summarized result: 1. The intervention group had a lower level of burden (p<0.05) than the control group intervention. 2. The level of quality of life was not significant during the intervention. According to this study a developed supportive musing intervention program is effective for reduction of the burden. For future research, it is necessary that experiments concerning quality of life in mothers of children with nephrotic syndrome, be conducted.