This study was done to examine the correlations between weight, BMI and risk factors of coronary heart disease in men and women in their forties and fifties. The subjects were 412 adults, who had regular health examinations between January and December of 1996 at S-Hospital in Seoul. The data were analyzed using ANOVA, Scheffe test, and Pearson correlation coefficient. The results are as follows : 1. The men between 50 and 59 years of age had higher levels for BMI, weight, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol, triglyceride, fasting blood sugar, plasminogen activator-1, and hemoglobin A1C than the group of women in their forties. Yet, HDL-cholesterol was lower than in the former group. 2. In the group of men in their forties, weight was significantly correlated to diastolic blood pressure(r=.22), LDL-cholesterol(r=.20), plasminogen activator inhibitor-1(r=.35) HDL-cholesterol(r=-.19). Their BMI was significantly corrected to systolic blood pressure(r=.27), diastolic blood pressure(r=.33), total cholesterol(r=.23), LDL-cholesterol(r=.26), plasminogen activator-1(r=.36) and HDL-cholesterol(r=-.25). 3. As for the group of women in their forties weight was significantly correlated to systolic blood pressure(r=.20), diastolic blood pressure(r=.22), triglyceride(r=.32), plasminogen activator inhibitor-1(r=.30) and HDL-cholesterol(r=-.37). Their BMI was significantly correlated to diastolic blood pressure(r=.25) triglyceride(r=.47), plasminogen activator-1(r=.35), fibrinogen(r=.27) and HDL-cholesterol(r=-.47). 4. In the group of men in their fifties, weight was significantly correlated to total cholesterol(r=.32), LDL-cholesterol(r=.29), plasminogen activator inhibitor-1(r=.26). Their BMI was significantly correlated to systolic blood pressure(r=.24), diastolic blood pressure(r=.22), total cholesterol(r=.34), LDL-cholesterol(r=.32), and plasminogen activator-1(r=.25). 5. In the group of women in their fifties, weight was significantly correlated to diastolic blood pressure(r=.33), total cholesterol(r=.21), LDL-cholesterol(r=.20), plasminogen activator inhibitor-1(r=.43) and HDL-cholesterol(r=-.21). Their BMI was significantly corrected to systolic blood pressure(r=.25), diastolic blood pressure(r=.40), total cholesterol(r=.24), LDL-cholesterol(r=.24), triglyceride(r=.22), and HDL-cholesterol(r=-.30). The above findings indicate that the BMI was more predictive than weight as a risk factor for coronary artery disease for men and women in their forties and fifties.