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Lee and Yoon: The Roles of Carbon Monoxide in Islets
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The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2007; 31(2): 97-104.

Published online: 31 March 2007

DOI: https://doi.org/10.4093/jkda.2007.31.2.97

The Roles of Carbon Monoxide in Islets

Hyoung Woo Lee, Ji Sung Yoon

Department of Internal Medicine, College of Medicine, Yeungnam University, Korea.

Copyright © 2007 Korean Diabetes Association

Figures and Tables

Fig. 1
Schematic of the heme oxygenase reaction.
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Fig. 2
The interactions of NO and CO on activating guanylate cyclase pathway.
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Fig. 3
Summary of the mechanism of CO's protection.
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Fig. 4
A, Quantitative analysis of HO-1 protein & mRNA expression in freshly isolated murine islets cultured in the presence of FePP; B, FePP-induced HO-1 upregulation results in partial protection from cytokine and Fas-mediated apoptosis induction in βTC3 cells40).
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Fig. 5
Time course of return to normoglycemia in mice that received a syngeneic marginal mass islet graft. A, time curve to normoglycemia of recipient mice that received FePP-treated islets (● vs control ○). MT to normoglycemia was 36 ± 28.9 days (P = ns); B, Time to normoglycemia of mice that received untreated islets and were treated in vivo with CoPP (□). MT was 33 ± 0.4 days (P = ns); C, Time to normoglycemia in mice that received FePP-treated islets and were treated in vivo with CoPP (■). MT was 18 ± 28.3 days (P = 0.006)40).
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Fig. 6
Exposure of murine islet to CO improves islet survival/function after transplantation.
*P = 0.001 vs. control46).
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Table 1
Summary of heme oxygenase (HO) isoforms
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