Journal List > J Korean Diabetes Assoc > v.31(6) > 1062473

Lee, Kim, Seo, Jeon, Moon, Kim, Doh, Kim, Kim, Yoo, and Lee: Association of Kir6.2 and Peroxisome Proliferator-activated Receptor-gamma (PPARγ) Polymorphisms with Type 2 Diabetes in Koreans



The type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Several variants may contribute significantly to the risk of type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). In this study, we evaluated the association of Pro12Ala variant of the peroxisome proliferator-activated receptor-γ and the Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11) with the type 2 diabetes in Korean population.


This study included 331 subjects consisting of 172 patients with type 2 diabetes and 159 non-diabetic control subjects enrolled from the Kyungpook, Keimyung and Catholic university hospital in Daegu, Korea. We genotyped Kir6.2 (Glu23Lys) and PPARγ (Pro12Ala) polymorphism and examined their association with the type 2 diabetes.


In the separate analyses, the Kir6.2 Glu23Lys (P = 0.385) and the PPARγ Pro12Ala (P = 0.191) polymorphism showed no significant association with type 2 diabetes. In addition, the results of our study showed no evidence of a synergistic interaction between Kir6.2 and PPARγ gene in each group (P = 0.110, P = 0.276).


In this study, no association was seen between the genetic polymorphisms of Kir6.2, PPARγ and type 2 diabetes. However, to clarify whether genetic polymorphisms of these genes contribute to the development of type 2 diabetes, further studies involving larger Korean populations may be needed.

Figures and Tables

Table 1
Dermographic and health behavior variables among study subjects

*expressed as mean ± SD. P < 0.05.

Table 2
Genotype and allele frequencies of Kir 6.2 gene in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Table 3
Genotype frequencies of Kir 6.2 gene by gender in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Table 4
Genotype and allele frequencies of PPARγ gene in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Table 5
Genotype frequencies of PPARγ gene by gender in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.

Table 6
Distribution of the genotype combination of Kir6.2 and PPARγ genes in both group

*odds ratio adjusted for age, sex, BMI, smoking status, drinking status. OR, odds ratio; T2D, type 2 diabetes mellitus.


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