Journal List > J Korean Diabetes Assoc > v.31(4) > 1062461

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Cho, Cho, Park, Kang, Kim, Ku, Lee, Park, Shin, Park, Kim, Cho, and Lee: Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus
Case Report
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2007; 31(4): 372-376.

Published online: 31 July 2007

DOI: https://doi.org/10.4093/jkda.2007.31.4.372

Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus

Hwa Young Cho, Young Min Cho, Myoung Hee Park1, Mi Yeon Kang, Ki Hwan Kim, Yun Hyi Ku, Eun Kyung Lee, Do Joon Park, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee

Department of Internal Medicine, Seoul National University College of Medicine, Korea.

1Department of Laboratory Medicine, Seoul National University College of Medicine, Korea.

Received 29 August 2006       Accepted 21 June 2007

Copyright © 2007 Korean Diabetes Association

Abstract

Autoantibody negative fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and a negative islet-related autoantibodies. The prevalence of fulminant type 1 diabetes has large difference between Japan and other countries. The precise reason for this regional variation remains to be clarified. One of the possible explanations is genetic background such as genotype of class II HLA molecule. In addition, environment factors including viral infection are suggested as possible pathogenesis of the disease. Only a few cases with fulminant type 1 diabetes have been reported outside Japan, and most of these cases with definite diagnosis have been reported in Korea. We report here on two Korean patients that met the criteria for diagnosis of fulminant type 1 diabetes in accordance with their HLA genotypes.

Keywords: Fulminant, Human leukocyte antigen, Type 1 diabetes mellitus

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