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Jung, Lee, and Shon: The Correlation between Central Obesity and Glucose, Lipid Metabolism and Macrovascular Complication in Elderly Type 2 Diabetes
Original Article
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2007; 31(4): 343-350.

Published online: 31 July 2007

DOI: https://doi.org/10.4093/jkda.2007.31.4.343

The Correlation between Central Obesity and Glucose, Lipid Metabolism and Macrovascular Complication in Elderly Type 2 Diabetes

Eui Dal Jung, Jihyun Lee, Ho-Sang Shon

Department of Internal Medicine, School of Medicine, Catholic University of Daegu, Korea.

Received 2 January 2007       Accepted 7 May 2007

Copyright © 2007 Korean Diabetes Association

Abstract

Background

Obesity is related to abnormal lipid metabolism and macrovascular complication and accumulated fat on the abdomen in elderly diabetic patients. The aim of this study was to compare elderly diabetic patients' body fat composition with middle-aged patients and evaluate the role of central obesity on glucose and lipid metabolism and macrovascular complications in elderly type 2 diabetic patients.

Methods

We defined elderly patients who are over 65 years old and who waist circumference is over than 90 cm in men and 85 cm in women and waist-hip ratio (WHR) was over than 0.90 in men and 0.85 in women defined central obesity. % body fat were measured a bioimpedence analysis using DSM (Direct Segmental Measurement by 8-point electrode) method (Inbody 3.0, Biospace, Seoul, Korea) in two hundred two type 2 diabetes. Laboratory parameters such as fasting blood glucose, HbA1c, and lipid profile were included in this study and also investigated the macrovascular complication.

Results

1) The ninety-five elderly diabetic patients, compared with middle-aged diabetic patients, were similar BMI and % of body fat but significantly increased waist circumference (P < 0.05) and WHR (P < 0.001). 2) In pearson's correlations, waist circumference was correlated with BMI (r = 0.927, P < 0.001), WHR (r = 0.851, P < 0.001), % body fat (r = 0.519, P < 0.001), total cholesterol (r = 0.255, P < 0.05), triglyceride (r = 0.365, P < 0.001), and LDL-cholesterol (r = 0.271, P < 0.05) in elderly diabetic patients. And WHR was also correlated with BMI (r = 0.744, P < 0.001), waist circumference (r = 0.851, P < 0.001), % body fat (r = 0.425, P < 0.001), total cholesterol (r = 0.372, P < 0.001), triglyceride (r = 0.408, P < 0.001), and LDL-cholesterol (r = 0.386, P < 0.001). 3) The obese elderly diabetic patients had increased triglyceride, total cholesterol and LDL-cholesterol but not related with macrovascular complication compared with lean elderly patients.

Conclusion

In elderly type 2 diabetic patients are more central obesity although the same weight compared with middle-aged patients. Waist circumference and WHR were highly correlated with body fat composition and lipid profile in elderly diabetes. In obese elderly patients have abnormal lipid profile but not more macrovascular complication.

Keywords: Central obesity, Lipid, Elderly diabetes, Macrovascular disease

Figures and Tables

Table 1
Anthropometric and biochemical data of the subjects
jkda-31-343-i001

*P < 0.05, **P < 0.001 vs middle-aged patients. BMI, body mass index; WC, waist circumference; WHR, waist hip ratio; FBS, fasting blood sugar; BP, blood pressure; T-Chol, total-cholesterol; TG, triglyceride; HDL, high density lipoprotein; LDL, low density lipoprotein; OHA, oral hypoglycemic agents.

Table 2
Correlation coefficient of several parameters with clinical and biochemical factors in elderly diabetic patients
jkda-31-343-i002

*P < 0.05, **P < 0.001 vs middle-aged patients. FBS, fasting blood sugar; BMI, body mass index, T-Chol, total-cholesterol; TG, triglyceride; HDL, high density lipoprotein; LDL, low density lipoprotein.

Table 3
Lipid metabolism and macrovascualr complication according to obesity category in elderly diabetic patients
jkda-31-343-i003

TG, triglyceride; T-Chol, total-cholesterol; LDL, low density lipoprotein.

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