Journal List > J Korean Diabetes Assoc > v.30(6) > 1062415

J Korean Diabetes Assoc. 2006 Nov;30(6):487-491. Korean.
Published online November 30, 2006.
Copyright © 2006 Korean Diabetes Association
Acquired Generalized Lipodystrophy with Severe Insulin Resistant Diabetes Mellitus
Jung Min Lee, Tae Seo Sohn and Hyun Shik Son
Department of Internal Medicine, Division of Endocrinology and Metabolism, The Catholic University of Korea, Korea.
Received October 24, 2006; Accepted November 25, 2006.


Acquired generalized lipodystrophy is a rare disease, and often follows autoimmune disease, prodromal infection, HIV infection. The clinical characteristics are generalized absence of fat, insulin resistance, diabetes mellitus, absence of ketosis, elevated basal metabolic rate, severe hypertriglyceridemia, and hepatomegaly. Here we experience and report a case of 16-year-old female patient who has clinical features of acquired generalized lipodystrophy with severe insulin resistant diabetes mellitus without any prodromal states.

Keywords: Diabetes mellitus; Hypertriglyceridemia; Lipodystrophy


Fig. 1
General appearance revealed a muscular hypertrophy, larger biacromial than bitrochanterian diameter, lack of subcutaneous fat on trunk and limbs, no development of breast.
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Fig. 2
MRI of the liver. Hepatomegaly and fatty changes were detected.
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Fig. 3
MRI of the thight. There ar no intramuscular fat deposit. But, bone marrow fat is preserved.
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