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Lee, Sohn, and Son: Acquired Generalized Lipodystrophy with Severe Insulin Resistant Diabetes Mellitus
Case Report
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2006; 30(6): 487-491.

Published online: 30 November 2006

DOI: https://doi.org/10.4093/jkda.2006.30.6.487

Acquired Generalized Lipodystrophy with Severe Insulin Resistant Diabetes Mellitus

Jung Min Lee, Tae Seo Sohn, Hyun Shik Son

Department of Internal Medicine, Division of Endocrinology and Metabolism, The Catholic University of Korea, Korea.

Received 24 October 2006       Accepted 25 November 2006

Copyright © 2006 Korean Diabetes Association

Abstract

Acquired generalized lipodystrophy is a rare disease, and often follows autoimmune disease, prodromal infection, HIV infection. The clinical characteristics are generalized absence of fat, insulin resistance, diabetes mellitus, absence of ketosis, elevated basal metabolic rate, severe hypertriglyceridemia, and hepatomegaly. Here we experience and report a case of 16-year-old female patient who has clinical features of acquired generalized lipodystrophy with severe insulin resistant diabetes mellitus without any prodromal states.

Keywords: Diabetes mellitus, Hypertriglyceridemia, Lipodystrophy

Figures and Tables

Fig. 1
General appearance revealed a muscular hypertrophy, larger biacromial than bitrochanterian diameter, lack of subcutaneous fat on trunk and limbs, no development of breast.
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Fig. 2
MRI of the liver. Hepatomegaly and fatty changes were detected.
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Fig. 3
MRI of the thight. There ar no intramuscular fat deposit. But, bone marrow fat is preserved.
jkda-30-487-g003

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