Journal List > J Korean Diabetes Assoc > v.30(6) > 1062411

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Kim, Kang, Kim, and Lee: Effect of Sea Tangle Powder on the Regulation of Blood Glucose Level and Body Weight in Streptozotocin (STZ)-induced Diabetic Rats
Original Article
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2006; 30(6): 459-465.

Published online: 30 November 2006

DOI: https://doi.org/10.4093/jkda.2006.30.6.459

Effect of Sea Tangle Powder on the Regulation of Blood Glucose Level and Body Weight in Streptozotocin (STZ)-induced Diabetic Rats

Hyung Woo Kim, Jae Seung Kang, Su In Kim1, Wang Jae Lee

Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University, College of Medicine, Korea.

1EntoPharm Co., Ltd, Korea.

Received 26 January 2005       Accepted 1 September 2006

Copyright © 2006 Korean Diabetes Association

Abstract

Background

Sea tangle is one of the low calorie diet and the fibers in sea tangle suppress the increase of blood glucose level. Therefore, it has a better impact than any other diets for diabetic patients. In the present study, we have investigated the effect of sea tangle powder, hereafter referred as Substance <D>, as an antihyperglycemic agent and antioxidant in streptozotocin (STZ)-induced diabetic rats.

Methods

Male Wistar rats were divided into three groups: group 1) vehicle-treated normal rats; group 2) vehicle-treated STZ-diabetic rats; group 3) sea tangle powder-treated STZ-diabetic rats. Fasting blood glucose levels and body weights were measured. Intracellular ROS levels were measured using Cytofluor 2350 plate reader.

Results

Oral administration of sea tangle powder for 10 days resulted in lowered levels of blood glucose in early stage (within a week) and preventing effect of weight loss in late stage. Treatment with sea tangle powder resulted in the decrease of intracellular ROS levels in Dendritic Cell line.

Conclusion

Sea tangle powder exhibits antihyperglycemic activity and restorative activity on weight loss in STZ-induced diabetic rats. It's abilities depend not on protecting disruption of β-cell, but on antioxidant effect in other organs.

Keywords: Antioxidant, Diabetes mellitus, Sea tangle powder

Figures and Tables

Fig. 1
Schedule for Induction of Diabetes, oral Feeding of Substance <D> and measurement of Fasting blood glucose (FBG) and body weight (B.W).
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Fig. 2
Effect of Substance <D> on blood glucose levels in early stage. Normal, vehicle-treated rat; DM Control, vehicle-treated STZ-diabetic rat; Substance <D>, Substance <D>-treated STZ-diabetic rats.
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Fig. 3
Effect of Substance <D> on blood glucose levels in late stage. Normal, vehicle-treated rat; DM Control, vehicle-treated STZ-diabetic rat; Substance <D>, Substance <D>-treated STZ-diabetic rats.
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Fig. 4
Effect of Substance <D> on body weight loss in diabetic rats. Normal, vehicle-treated rat; DM Control, vehicle-treated STZ-diabetic rat; Substance <D>, Substance <D>-treated STZ-diabetic rats.
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Fig. 5
Effect of Substance <D> on intracellular ROS levels in normal cells. Negative control, Cell only; Control, Cell + 50 µM DCTH-DA; Substance <D> treated Cell + 50 µM DCTH-DA+ Substance <D> (1 : 200 dilution). Results are representative of three experiments.
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Table 1
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Table 2
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Table 3
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Table 4
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