Journal List > J Korean Diabetes Assoc > v.30(6) > 1062409

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Kim, Park, Nam, Kim, Park, Nam, Park, Lee, and Kim: Prevalence of Metabolic Syndrome in Type 2 DM Patients with Non-alcoholic Fatty Liver
Original Article
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2006; 30(6): 442-449.

Published online: 30 November 2006

DOI: https://doi.org/10.4093/jkda.2006.30.6.442

Prevalence of Metabolic Syndrome in Type 2 DM Patients with Non-alcoholic Fatty Liver

Ji Min Kim3, Ja Young Park, Hyn Kyung Nam, Ja Won Kim, Su Kyung Park, Kyung Jin Nam1, Mi-Kyoung Park, Hye-Jeong Lee2, Duk Kyu Kim

Department of Internal Medicine, Dong-A University College of Medicine, Korea.

1Department of Radiology, Dong-A University College of Medicine, Korea.

2Department of Pharmacology, Dong-A University College of Medicine, Korea.

3Department of Internal Medicine, Hanseo Hospital, Korea.

Received 8 April 2006       Accepted 1 November 2006

Copyright © 2006 Korean Diabetes Association

Abstract

Background

Non-alcoholic fatty liver is rendered as one component of metabolic syndrome (MS). We evaluated the prevalence of MS as well as clinical and laboratory characteristics of Type 2 DM patients with non-alcoholic fatty liver.

Methods

Fatty liver group (n = 71) who showed significant fatty change by ultrasonography and age, sex matched control group (n = 40) were studied retrospectively. We compared demographic and laboratory findings and prevalence of MS by modified WHO criteria and new IDF criteria between both groups.

Results

There were no significant difference in age, DM duration, BMI, prevalence of hypertension, coronary artery disease, CVA, diabetic retinopathy, neuropathy, nephropathy between both groups. In fatty liver group, the plasma level of FBS, TG, ALT, total protein, albumin and GGT were significantly higher than those of control group (P = 0.033, P = 0.000, P = 0.002, P = 0.008, P = 0.003, P = 0.001). The plasma levels of HDL-C in fatty liver group were significantly lower than those of control group (P = 0.013). The plasma level of FBS, FFA, TG, total protein, albumin, ALT, HOMAIR and BMI were significantly related to the severity of fatty liver. The prevalence of MS in fatty liver group was significantly higher than that of control group by modified WHO criteria (P = 0.001) or new IDF criteria (P = 0.036).

Conclusion

Type 2 DM patients with nonalcoholic fatty liver frequently accompanied the metabolic syndrome. They showed nonspecific changes in the liver function tests.

Keywords: Metabolic syndrome, Non-alcoholic fatty liver, Type 2 DM

Figures and Tables

Table 1
Clinical Characteristics of the Subjects
jkda-30-442-i001

Data was expressed as mean ± SD.

NS, not significant; MS, metabolic syndrome; CAD, coronary artery disease; PVD, peripheral vascular disease; CVA, cerebrovascular disease; TG, Triglyceride; HDL-C, high density lipoprotein-cholesterol; TC, total cholesterol; LDL-C, low density lipoprotein-cholesterol; FFA, Free fatty acid; Lp(a), lipoprotein(a); FBS, fasting blood sugar; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transferase.

Table 2
Prevalences of Metabolic Syndrome and Microalbuminuria in the Subjects
jkda-30-442-i002

MS, metabolic syndrome; m, modified; n, new.

Table 3
Prevalence of Metabolic Syndrome in the Three Groups Divided by the Severity of Fatty Liver
jkda-30-442-i003

NS, not significant between each group; m WHO means modified WHO criteria, n IDF means new IDF criteria

Table 4
Liver Function Test Findings and Prevalence of Metabolic Syndrome in the Normal and Microalbuminuric Patients
jkda-30-442-i004

TP, Total protein; Alb, Albumin; MS, Metabolic syndrome; mWHO, means modified WHO criteria; nIDF means new IDF criteria, P means P value.

Table 5
Correlation between Parameters and Severity of Fatty Liver
jkda-30-442-i005

FFA, Free fatty acid; FBS, fasting blood sugar; TP, Total protein.

Table 6
Metabolic Components of Metabolic Syndrome in the Subjects
jkda-30-442-i006

There were no significant differences of the prevalence of metabolic syndrome between each control groups and between each fatty liver group by modified (m) WHO criteria or new (n) IDF criteria.

DM, type 2 DM; OB, central obesity; HT, Hypertension; TG, Triglyceride.

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