Journal List > J Korean Diabetes Assoc > v.30(3) > 1062378

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Park, Kang, Chon, Oh, Woo, Kim, Kim, and Kim: The Clinical Characteristics of Young Onset Diabetes According to Etiology Based Classification
Original Article
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2006; 30(3): 190-197.

Published online: 31 May 2006

DOI: https://doi.org/10.4093/jkda.2006.30.3.190

The Clinical Characteristics of Young Onset Diabetes According to Etiology Based Classification

Mina Park1, Yang-Il Kang1, Suk Chon1, 2, Seung-joon Oh1, 2, Jeong-taek Woo1, 2, Sung-Woon Kim1, 2, Jin-Woo Kim1, 2, Young-Seol Kim1, 2

1Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Korea.

2Endocrine Research Institute, College of Medicine, Kyung Hee University, Korea.

Received 7 October 2005       Accepted 17 May 2006

Copyright © 2006 Korean Diabetes Association

Abstract

Background

Recently, the number of young diabetic patients is increasing. It is important to understand the characteristics of young diabetes and classify it correctly to manage these patients successfully. We aimed to classify young onset diabetes according to etiology and evaluate the clinical characteristics.

Methods

Young patients (15~30 years old) who have been treated diabetes in Kyunghee medical center in 2004 were included. We investigated family history of diabetes, disease duration, body mass index (BMI), the history of diabetic ketoacidosis, HbA1c, fasting C-peptide, autoantibody, lipid profile and treatment method via medical records.

Results

Total 85 patients (M:F 40:45) were evaluated. Type 1 diabetes was 45.9%, type 2 diabetes was 23.5% and unclassified group was 25.9%. Many type 2 diabetic patients were overweight or obese (94.8%). Most young diabetic patients were using insulin (95.4%). Many type 1 diabetic patients have been treated by insulin only and many type 2 diabetic patients have been received combined therapy of insulin and oral hypoglycemic agent. The recent HbA1c was average 8.32 ± 2.7%. The prevalence of diabetic retinopathy, neuropathy and nephropathy was 32.9%, 22.4% and 16.4% as each.

Conclusion

Nearly half of young onset diabetes was type 1 diabetes but many others were also classified to type 2 diabetes or unclassified group. It is important to provide a consistent algorithm for assessment and investigation for newly diagnosed young diabetic patients. More education and effort are required to control diabetes strictly and prevent its complication.

Keywords: Autoantibody, C-peptide, Type 1 diabetes, Type 2 diabetes

Figures and Tables

Table 1
Baseline Characteristics of Young Diabetic Patients (15~30 years) According to Etiology Based Classification
jkda-30-190-i001

*Data: mean ± SD or number (%), BMI: body mass index.

*Others: Diabetes after pancreatectomy (2) or gestational DM (2).

Table 2
Clinical and Biochemical Characteristics of Young Diabetic Patients at Diagnosis
jkda-30-190-i002

*Data: number (% within each type) or mean ± SD

*T1DM, Type 1 diabetes mellitus; T2DM, Type 2 diabetes mellitus; BMI, body mass index; C-peptide, fasting C-peptide; ACR, acute c-peptide response to oral glucose (75 g) during first 30 min; Insulinogenic index, acute insulin response to oral glucose (75 g) during first 30 min; ns, not significant.

Table 3
Treatment Modality According to the Type of DM
jkda-30-190-i003
Table 4
The Current Biochemical Laboratory Data of Young Diabetic Patients
jkda-30-190-i004

*Data: mean ± SD or number of patients, ns: not significant.

Table 5
The Clinical and Biochemical Characteristics of Young Diabetic Patients According to HbA1c.
jkda-30-190-i005

*Data: number (%), mean ± SD, ns: not significant.

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