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Chung, Choi, Park, Kim, Chang, Kim, and Kim: Transbronchial Needle Aspiration in the Diagnosis of Submucosal and Peribronchial Bronchogenic Carcinoma
Original Article

Tuberculosis and Respiratory Diseases 2004; 56(4): 374-380.

Published online: 30 April 2004

DOI: https://doi.org/10.4046/trd.2004.56.4.374

Transbronchial Needle Aspiration in the Diagnosis of Submucosal and Peribronchial Bronchogenic Carcinoma

Jae Ho Chung, M.D.1, Jeong Eun Choi, M.D.1, Moo Suk Park, M.D.2, Young Sam Kim, M.D.2, 3, Joon Chang, M.D.2, 3, Sung Kyu Kim, M.D.2, 3, Se Kyu Kim, M.D.2, 3, 4, 5

1Department of Internal Medicine, Kwandong University College of Medicine, Myongji Hospital, Goyang, Korea.

2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

3The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.

4Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.

5Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea.

Address for correspondence: Se Kyu Kim, M.D. Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Ku, Seoul 120-752, South Korea. Phone: 82-2-361-5429, Fax: 82-2-393-6884, sekyukim@yumc.yonsei.ac.kr

Copyright©2004. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Although exophytic endobronchial lesions can readily be diagnosed by routine forceps biopsy through the fiberoptic bronchoscope, submucosal or peribronchial tumor can be difficult to diagnose. So we evaluated the diagnostic utility of transbronchial needle aspiration (TBNA) through the fiberoptic bronchoscope in patients presenting with endoscopic abnormalities suggestive of submucosal or peribronchial tumor.

Patients and Methods

Retrospective review of 120 lung cancer patients who were found to have the lesions suggestive of peribronchial and submucosal tumor during fiberoptic bronchoscopy was performed from Jan. 1994 to Dec. 2002 at Severance Hospital, Yonsei University College of Medicine.

Methods

Forcep biopsy was positive in 63 cases (52.5%) and TBNA in 91 (75.8%), which was significantly better than forcep biopsy (p=0.001). The combination of forceps biopsy and TBNA was positive in 106 cases (88.3%), which was significantly better than forceps biopsy alone (p=0.0001). The difference of TBNA yield according to cell type or bronchoscopic appearance of lesion was not significant, but it showed the relatively better result in small cell carcinoma.

Conclusions

We concluded that TBNA significantly increase the yield over forcep biopsy alone in the detection of submucosal or peribronchial bronchogenic carcinoma.

Keywords: Transbronchial needle aspiration, Lung cancer, Peribronchial, Submucosal

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