Appropriate pathologic diagnosis of small cell lung cancer (SCLC) is essential in order to apply the aggressive treatment modalities. But several subtypes of SCLC were suggested by various authors based on morphological features. Among them, the incidence of small cell lung cancer (SCLC) combined with squamous cell and/or adenocarcinoma, combined small cell lung cancer, represent less than 1% to 3% of SCLC tumors. Because of the rarity of SCLC combined with squamous cell and/or adenocarcinoma, very little is known about the clinical characteristics and response to therapy of these tumor. We report a case of SCLC combined with squamous cell and adenocarcinoma in 68 year old male who experienced pneumonectomy of the left lung.