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Kwon, Kim, Kim, and Chun: Acetylcholinesterase Inhibitors from Angelica polymorpha Stem
Original Article

Natural Product Sciences 2017;23(2):97-102.

Published online: 20 January 2017

DOI: https://doi.org/10.20307/nps.2017.23.2.97

Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

Yongsoo Kwon1, ∗, Hyun Pyo Kim1, Myong Jo Kim2, Wanjoo Chun3

1College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea

2College of Agriculture and Life science, Kangwon National University, Chuncheon 24341, Korea

3School of Medicine, Kangwon National University, Chuncheon 24341, Korea

∗Author for correspondence Yongsoo Kwon, College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea Tel: +82-33-250-6921; E-mail: yskwon@kangwon.ac.kr

Received 15 December 2016       Revised 23 January 2017       Accepted 24 January 2017

Copyright © 2017 The Korean Society of Pharmacognosy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (−)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (–)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4 – 6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with IC50 values ranging from 1.4 to 37.5 µM.

Keywords: Angelica polymorpha, Coumarins, Chromones, Acetylcholinesterase inhibitory effect

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Fig. 1.
Structures of 1 – 14.
nps-23-97f1.tif
Table 1.
Acetylcholinesterase inhibitory activity of compounds 1 – 14
Tested compounds IC501) (µg/ml) IC50 (µM)
1 7.7 28.5
2 1.3 4.0
3 0.3 1.4
4 2.0 8.8
5 1.9 6.3
6 2.5 9.7
7 4.0 12.6
8 2.0 8.7
9 2.7 10.4
10 6.9 23.2
11 2.4 8.7
12 4.3 12.9
13 7.2 37.5
14 > 100 −
Galanthamine-hydrobromide2) 0.3 0.8

1) The inhibitory activity dose that reduced 50% of aceylcho-lineseterase activity and expressed as mean of two different experiments.

2) A positive control.

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