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Woo, Jung, Lee, Kim, Kim, Jung, An, Ham, Jeon, and Cho: Phytochemical Constituents from the Rhizomes of Osmunda japonica Thunb and Their Anti-oxidant Activity
Original Article

Natural Product Sciences 2017;23(3):217-221.

Published online: 20 January 2017

DOI: https://doi.org/10.20307/nps.2017.23.3.217

Phytochemical Constituents from the Rhizomes of Osmunda japonica Thunb and Their Anti-oxidant Activity

Kyeong wan Woo1, †, Ja Kyun Jung1, †, Hyun Joo Lee1, Tae Muk Kim1, Min Suk Kim1, 2, Ho Kyung Jung1, Byeongkwan An1, Seong Ho Ham1, Byung Hun Jeon2, Hyun Woo Cho1, ∗

1Traditional Korean Medicine Research Team, National Development Institute of Korea Medicine, 288, Woodlandgil, Anyangmyeon, Jangheunggun, Jeollanamdo 59338, Republic of Korea

2Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan 54538, Republic of Korea

∗Author for correspondence Hyun Woo Cho, Traditional Korean Medicine Research Team, National Development Institute of Korea Medicine, Jangheunggun 59338, Jeollanamdo, Republic of Korea. Tel: +82-61-860-2801; E-mail: johw7@nikom.or.kr

a† These authors contributed equally to this work.

Received 29 May 2017       Revised 5 July 2017       Accepted 7 July 2017

Copyright © 2017 The Korean Society of Pharmacognosy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Eleven compounds (1–11) were isolated from the rhizomes of Osmunda japonica, and their structures were elucidated based on1H,13C-NMR and LC-IT-TOF MS data. Of these compounds, all compounds (1 – 11) have been previously reported, although five (6 – 9, 11) have not previously been isolated from this plant. The antioxidant activities of isolated compounds (1 – 11) were measured by DPPH and ABTS assays, and compound 10 showed the high antioxidant activity.

Keywords: Osmunda japonica, Osmundaceae, Chemical constituents, Anti-oxidant

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Fig. 1.
The structures of 1 – 11 isolated from O. japonica.
nps-23-217f1.tif
Table 1.
The antioxidant activities of O. japonica compounds (1 – 11)∗
Compound IC50 (µM)
DPPH ABTS
1 >1000 >1000
2 >1000 >1000
3 >1000 >1000
4 153.6 ± 4.21 227.7 ± 2.45
5 >1000 >1000
6 >1000 75.6 ± 1.54
7 237.8 ± 6.31 >1000
8 >1000 120 ± 3.72
9 256.3 ± 5.19 >1000
10 9.1 ± 0.14 16.1 ± 1.45
11 92.4 ± 4.52 107.2 ± 6.23
Ascorbic acid 3.9 ± 0.21 14.1 ± 2.80

∗ Each value in the tables is represented as mean ± S.D. (n = 3).

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