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Tao, Liu, Jung, Guo, Wen, and Liu: Compounds from a jellyfish-derived fungus Aspergillus fumigates
Original Article

Natural Product Sciences 2016;22(2):82-86.

Published online: 17 December 2016

DOI: https://doi.org/10.20307/nps.2016.22.2.82

Compounds from a jellyfish-derived fungus Aspergillus fumigates

Guan-yu Tao1, 2, Juan Liu1, Jee H. Jung3, Wei Guo4, Xiao-qiong Wen4, Yonghong Liu1, 5, ∗

1Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 510301 Guangzhou, China

2School of Life Science, South China Normal University, 510361 Guangzhou, China

3College of Pharmacy, Pusan National University, Busan 609-735, Korea

4School of Traditional Chinese Medicine, Southern Medical University, 510515 Guangzhou, China

5South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center

∗Author for correspondence Yonghong Liu, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 510301 Guangzhou, China Tel: +86-020-89023244; E-mail: yonghongliu@scsio.ac.cn

Received 6 August 2015       Revised 21 October 2015       Accepted 22 October 2015

Copyright © 2016 The Korean Society of Pharmacognosy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), (22 E, 24 R)-24-methyl-5α-cholesta-7,22-diene-3β,5,6β-triol (3), 5α,8α-epidioxyergosta-6,22-dien-3β-o1 (4), cyclo-(L-Pro-L-Tyr) (5), fumitremorgin C (6). The compounds 1–5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1–6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.

Keywords: Nemopilema nomurai, Jellyfish-derived fungus, Aspergillus fumigates, Isolation, Structural elucidation

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Fig. 1.
The structures of the compounds from the jellyfish-derived fungus Aspergillus fumigatus.
nps-22-82f1.tif
Fig. 2.
CD spectra of compounds 1 and 2.
nps-22-82f2.tif
Fig. 3.
Proposed biosynthetic pathway of compounds 1 and 2.
nps-22-82f3.tif
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