Journal List > Korean J Endocr Surg > v.9(3) > 1060365

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Lee, Lee, Kim, Kim, Lee, Kim, Ahn, Kim, and Lee: The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis
Original Article

Korean Journal of Endocrine Surgery 2009; 9(3): 155-160.

Published online: 30 September 2009

DOI: https://doi.org/10.16956/kjes.2009.9.3.155

The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis

Kwan Ju Lee, M.D., Jung Hea Lee, M.D.1, Jeong Soo Kim, M.D., Tai Gyu Kim, M.D.2, Sang Chul Lee, M.D., Jeong Goo Kim, M.D., Chang-Joon Ahn, M.D., Say June Kim, M.D., Dong Ho Lee, M.D.

Department of Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.

1Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.

2Department of Microbiology, The Catholic University of Korea College of Medicine, Seoul, Korea.

Correspondence: dongho@catholic.ac.kr

      Accepted 2 September 2009

Copyright © 2009 Korean Association of Thyroid and Endocrine Surgeons; KATES

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis.

Methods

This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells.

Results

Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P<0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009).

Conclusion

An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery.

Keywords: Papillary thyroid cancer, Fine needle aspiration, p27, Lymph node metastasis

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