Journal List > Korean J Endocr Surg > v.8(1) > 1060351

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Rhee, Koh, Kim, Koh, Kim, Choi, Park, and Park: Characteristics and Detection Rate of Thyroidal Incidentaloma using 18F-FDG PET-CT
Original Article

Korean Journal of Endocrine Surgery 2008; 8(1): 38-42.

Published online: 31 March 2008

DOI: https://doi.org/10.16956/kjes.2008.8.1.38

Characteristics and Detection Rate of Thyroidal Incidentaloma using 18F-FDG PET-CT

Kang Young Rhee, M.D., Gun Koh, M.D.1, Sun Kuk Kim, M.D.1, Jin Chul Koh, M.D.1, Haeng Soo Kim, M.D., Sang Yong Choi, M.D., Shin Hee Park, M.D., Yong Whi Park, M.D.2

Department of Surgery, Gwangmyeong Sungae General Hospital, Gwangmyeong, Korea.

1Department of Surgery, Sungae General Hospital, Seoul, Korea.

2Department of Nuclear Medicine, Sungae General Hospital, Seoul, Korea.

Correspondence: sungaegs@sungae.co.kr

      Accepted 18 March 2008

Copyright © 2008 Korean Association of Thyroid and Endocrine Surgeons; KATES

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/1.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the 18F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV).

Methods

18F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation.

Results

The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001).

Conclusion

PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase.

Keywords: Thyroid, Thyroid cancer, 18F-FDG PET-CT, SUV, Incidentaloma

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