Abstract
Purpose
This study analyzes the clinical characteristics of thyroid cancer patients over 70 years of age following thyroidectomy. We identified the differences among previous studies and investigated the significance of thyroidectomy for elderly thyroid cancer patients.
Methods
Information was abstracted from the charts of fifty-six patients treated during the period of Jan. 1995 to Dec. 2015. The abstraction included gender, age, surgical method, location with size of the main lesion, extent of lymph node metastasis, pathological features, gene mutation, complication, stage and most recent visit.
Results
Our study showed a frequent occurrence (96.4% of the study group) of papillary thyroid cancers in elderly patients. There were three cases of postoperative complications. None had recurrence, and there was only one death due to complications of pneumonia. There were 11 advanced cases of cancer stage IV.
Conclusion
Previous studies show that postoperative prognosis of elderly thyroid cancer patients is favorable. Average life expectancy is rising in South Korea, and therefore, the number of elderly thyroid cancer patients is increasing. Our study is meaningful in that it confirms the results of previous studies by surveying elderly patients over a 20 year period. It is deemed necessary that thyroidectomy be performed on elderly patients.
References
1. Kweon SS, Shin MH, Chung IJ, Kim YJ, Choi JS. Thyroid cancer is the most common cancer in women, based on the data from population-based cancer registries, South Korea. Jpn J Clin Oncol. 2013; 43:1039–46.
2. Park SH, Lee B, Lee S, Choi E, Choi EB, Yoo J, et al. A qualitative study of women's views on overdiagnosis and screening for thyroid cancer in Korea. BMC Cancer. 2015; 15:858.
3. Korean Surgical Society. Textbook of surgery. Seoul: Koonja;2011. p. 980–1004.
4. Vini L, Hyer SL, Marshall J, A'Hern R, Harmer C. Long-term results in elderly patients with differentiated thyroid carcinoma. Cancer. 2003; 97:2736–42.
5. Santangelo G, Del Giudice S, Gallucci F, Parmeggiani U, De Falco M. Cancer of the thyroid gland in geriatric age: a single center retrospective study with a 10-year post-operative follow-up. Int J Surg. 2014; 12(Suppl 2):S103–7.
6. Nguyen QT, Lee EJ, Huang MG, Park YI, Khullar A, Plodkowski RA. Diagnosis and treatment of patients with thyroid cancer. Am Health Drug Benefits. 2015; 8:30–40.
7. Raffaelli M, Bellantone R, Princi P, De Crea C, Rossi ED, Fadda G, et al. Surgical treatment of thyroid diseases in elderly patients. Am J Surg. 2010; 200:467–72.
8. Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B, et al. Multifactorial index of cardiac risk in non-cardiac surgical procedures. N Engl J Med. 1977; 297:845–50.
9. Kim E, Choi JY, Lee KE. Management of thyroid nodules and cancers arising in the elderly. J Korean Thyroid Assoc. 2012; 5:99–103.
10. Park HS, Jung CK, Lee SH, Chae BJ, Lim DJ, Park WC, et al. Clinicopathologic characteristics and surgical outcomes of elderly patients with thyroid cancer. Jpn J Clin Oncol. 2014; 44:1045–51.
11. Marvin K, Parham K. Differentiated thyroid cancer in people aged 85 and older. J Am Geriatr Soc. 2015; 63:932–7.
12. Cho BY, Choi HS, Park YJ, Lim JA, Ahn HY, Lee EK, et al. Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades. Thyroid. 2013; 23:797–804.
13. Lee SH, Kim TY, Ryu JS, Gong G, Kim WB, Kim SC, et al. Trends analysis of characteristics of thyroid cancer patients in one medical center. J Korean Endocr Soc. 2008; 23:35–43.
14. Chow SM, Law SC, Au SK, Mang O, Yau S, Yuen KT, et al. Changes in clinical presentation, management and outcome in 1348 patients with differentiated thyroid carcinoma: experience in a single institute in Hong Kong, 1960–2000. Clin Oncol (R Coll Radiol). 2003; 15:329–36.
15. Howlander N, Noone AM, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER cancer statistics review, 1975–2008. Bethesda: National Cancer Institute;2008.
16. Elisei R, Molinaro E, Agate L, Bottici V, Masserini L, Ceccarelli C, et al. Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question. J Clin Endocrinol Metab. 2010; 95:1516–27.
18. Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, et al. Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol. 2015; 33:42–50.
Table 1.
Table 2.
Table 3.
Characteristics | Current study | Cho (12) | Lee (13) | Chow (14) | Howlander (15) | Elisei (16) |
---|---|---|---|---|---|---|
No. of subjects | 56 | 2,900 | 4,646 | 733 | 2,400 | 2,972 |
Sex (Female %) | 80.3% | 82% | 86.5% | 80% | 73% | 74.8% |
Age | 72.9±2.6 | 49±12 | – | 47±16 | 46 (median) | 43±14 |
Size | 1.6±1.4 | 1.4±1.2 | – | 2.5 cm (average) | – | – |
<2 cm | 73% | 30.5% | 75.6% | – | – | – |
2∼4 cm | 21% | 40.2% | 20.1% | – | – | – |
>4 cm | 6% | 29.3% | 4.3% | – | – | – |
PTMC* | 43% | 43.1% | – | 21.7% | – | 28.7% |
Papillary carcinoma | 96.4% | 91.5% | 90.8% | 88% | 88% | 91% |
Follicular carcinoma | 1.7% | 7.3% | 4.9% | 12% | 9% | 9% |
Invasion | ||||||
LN metastasis | 20% | 44.4% | – | 24.8% | 25% | 22.4% |
Extrathyroidal extension | 35% | 54.8% | – | 42.7% | – | 18.3% |
Recurrence | 0% | 7.6% | – | 14.1% | – |