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Abstract
Hyalinizing trabecular tumor (HTT), a type of thyroid lesion, was first reported by Carney in 1987 and has since been reported continuously. Due to its histological non-specificity, HTT can be misdiagnosed as papillary thyroid cancer or medullary thyroid cancer. For this reason, over treatment might occur; for example, total thyroidectomy and lymphadenectomy. Diagnosis and treatment is a challenge because there is still controversy regarding HTT characters. We report on two cases. One patient was a 48-year-old female and the other was a 46-year-old female. Both patients complained of a thyroid mass and were diagnosed as HTT.
References
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Fig. 1.
Case 1. Ultrasonography feature of 48-year-old women. Transverse and longitudinal sonogram shows a 2.8 cm solid, cystic and heterogeneous mass in right lobe of thyroid (A). Transverse and longitudinal sonogram show a 1.7 cm solid, cystic and well defined heterogeneous mass in left lobe of thyroid, Fine needle aspiration was done two mass.
Fig. 2.
On frozen section show the cluster of tumor cells reveal nuclear overlapping and nuclear inclusion (arrow), which can be misinterpreted as papillary carcinoma (H&E stain, ×100 (A), ×400 (B)).
Fig. 3.
The Ki-67 staining characteristic membranous staining. The endothelial cell or inflammatory cell show usual nuclear staining pattern (arrow). ×400 (A, B).
Fig. 4.
Case 2. Ultrasonography feature of 48-year-old women. Transverse and longitudinal sonogram show a 1 cm solid, heterogeneous and intermediate mass, a 0.7 cm irregular hypoechoic mass which suggested malignant lesion in right lobe of thyroid. (A) Transverse and longitudinal sonogram show a 0.9 cm heterogeneous hypoechoic mass in left lobe of thyroid. (B) Fine needle aspiration was done right 0.7 cm, left 0.9 cm mass.
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