Journal List > Korean J Endocr Surg > v.12(1) > 1060064

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Choi, Kim, Park, Bae, and Kang: Association of BRAFV600E Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma
Original Article

Korean Journal of Endocrine Surgery 2012; 12(1): 16-20.

Published online: 31 March 2012

DOI: https://doi.org/10.16956/kjes.2012.12.1.16

Association of BRAFV600E Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma

Hyang Suk Choi, M.D., Kwang Min Kim, M.D., Joon Beom Park, M.D., Keum Seok Bae, M.D., Seong Joon Kang, M.D.

Department of Surgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.

Correspondence: mdkang@yonsei.ac.kr

Received 29 December 2011       Revised 1 February 2012       Accepted 2 February 2012

Copyright © 2012 Korean Association of Thyroid and Endocrine Surgeons; KATES

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study evaluated the association of the BRAFV600E mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma.

Methods

Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011.

Results

Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAFV600E mutation. Neither age nor sex were associated with the BRAFV600E mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAFV600E mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation.

Conclusion

As debate remains about the association between the BRAFV600E mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed.

Keywords: BRAFV600E mutation, Clinicopathologic factors, Ultrasonographic characteristics

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