Urothelial Changes by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome

Hoon Choi; Jae Hyun Bae

doi:10.14777/kjutii.2013.8.2.83

Journal List > Korean J Urogenit Tract Infect Inflamm > v.8(2) > 1059934

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Choi and Bae: Urothelial Changes by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome

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Korean J Urogenit Tract Infect Inflamm 2013;8(2):83-89.

Published online: 17 October 2013

DOI: https://doi.org/10.14777/kjutii.2013.8.2.83

Urothelial Changes by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome

Hoon Choi, Jae Hyun Bae

Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea

Correspondence to: Jae Hyun Bae, Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan 425-707, Korea Tel: +82-31-412-5190, Fax: +82-31-412-5194 E-mail: urobae@genetherapy.or.kr

No potential conflict of interest relevant to this article was reported.

Received 21 March 2013 Revised 14 April 2013 Accepted 15 April 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic disease. Symptoms of IC are often exacerbated by bladder filling and are associated with various urinary symptoms. IC is diagnosed by exclusion steps for differentiation from other confusable diseases. The pathophysiology and etiology of BPS/IC is not completely understood. IC is generally assumed to involve changes in the bladder wall as well as alterations in both structural abnormality of pain processing and its modulation. Alterations of the bladder wall at the molecular and structural levels in urothelium along with their adjacent structures have been observed in human patients. Bladder nerves, urothelial cells, and smooth muscles are likely to play an important role through active communication with the immune and inflammatory systems. This review provides recent information on patients with PBS/IC and their abnormalities within the bladder.

Keywords: Intersititial cystitis, Urothelium, Inflammation

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