Journal List > Korean J Urogenit Tract Infect Inflamm > v.8(1) > 1059932

Chung: Chronic Prostatitis/Chronic Pelvic Pain Syndrome: What Are the Starting and Worsening Factors?

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in the absence of any identifiable pathology such as cancer, curable infection, or anatomic abnormalities is defined as “urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months”. However, etiologic factors of CP/CPPS remain unknown. The traditional marker of inflammation, namely white blood cells in prostatic fluids, dose not correlate with the predominant symptom of pelvic pain. The role of normal bacterial flora in prostate in inciting the inflammatory response has also been reconsidered. Nanobacterial infection might be an important etiologic factor of type III prostatitis. An imbalance toward increased proinflammatory and decreased anti-inflammatory cytokines has been implicated, and its correlation with pelvic pain has also been observed to some extent. Pelvic pain also correlates with the neurotrophin (nerve growth factor) implicated in neurogenic inflammation and central sensitization. Finally, psychological stress may produce measurable biochemical changes and affect other processes. Here, the author reviewed the existing literature on etiology involved in the mechanisms of CP/CPPS.

REFERENCES

1. Cho IR. Evaluation and treatment of patients with prostatitis. Korean J Androl. 2005; 23:1–11.
2. Collins MM, Stafford RS, O'Leary MP, Barry MJ. How common is prostatitis? A national survey of physician visits. J Urol. 1998; 159:1224–8.
crossref
3. Woo YN. Prostatitis. Korean J Urol. 1994; 35:575–85.
4. Krieger JN, Egan KJ, Ross SO, Jacobs R, Berger RE. Chronic pelvic pains represent the most prominent urogenital symptoms of "chronic prostatitis". Urology. 1996; 48:715–21.
crossref
5. Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999; 282:236–7.
crossref
6. Pontari MA, Ruggieri MR. Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol. 2008; 179(5 Suppl):S61–7.
crossref
7. Berger RE, Krieger JN, Rothman I, Muller CH, Hillier SL. Bacteria in the prostate tissue of men with idiopathic prostatic inflammation. J Urol. 1997; 157:863–5.
crossref
8. Mehik A, Hellstrom P, Sarpola A, Lukkarinen O, Jarvelin MR. Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int. 2001; 88:35–8.
crossref
9. Ponniah S, Arah I, Alexander RB. PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome. Prostate. 2000; 44:49–54.
crossref
10. Zermann DH, Ishigooka M, Doggweiler R, Schmidt RA. Neurourological insights into the etiology of genitourinary pain in men. J Urol. 1999; 161:903–8.
crossref
11. Ha JS, Kim SW, Cho YH. Detection of cryptic microorganisms by polymerase chain reaction assay in chronic pelvic pain syndrome. Korean J Urol. 2002; 43:396–401.
12. Jung SG, Lee SD. Correlation between genitourinary Mycoplasmas and Chlamydia infection and chronic prostatitis/chronic pelvic pain syndrome. Korean J UTII. 2011; 6:67–72.
13. Berger RE, Krieger JN, Kessler D, Ireton RC, Close C, Holmes KK, et al. Case-control study of men with suspected chronic idiopathic prostatitis. J Urol. 1989; 141:328–31.
crossref
14. Shen X, Ming A, Li X, Zhou Z, Song B. Nanobacteria: a possible etiology for type III prostatitis. J Urol. 2010; 184:364–9.
crossref
15. Shoskes DA, Thomas KD, Gomez E. Anti-nanobacterial therapy for men with chronic prostatitis/chronic pelvic pain syndrome and prostatic stones: preliminary experience. J Urol. 2005; 173:474–7.
crossref
16. Zhou Z, Hong L, Shen X, Rao X, Jin X, Lu G, et al. Detection of nanobacteria infection in type III prostatitis. Urology. 2008; 71:1091–5.
crossref
17. Kim TH, Kim HR, Myung SC. Detection of nanobacteria in patients with chronic prostatitis and vaginitis by reverse transcriptase polymerase chain reaction. Korean J Urol. 2011; 52:194–9.
crossref
18. Stancik I, Plas E, Juza J, Pfluger H. Effect of antibiotic therapy on interleukin-6 in fresh semen and postmasturbation urine samples of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology. 2008; 72:336–9.
crossref
19. Liu L, Li Q, Han P, Li X, Zeng H, Zhu Y, et al. Evaluation of interleukin-8 in expressed prostatic secretion as a reliable biomarker of inflammation in benign prostatic hyperplasia. Urology. 2009; 74:340–4.
crossref
20. Lotti F, Corona G, Mancini M, Filimberti E, Degli Innocenti S, Colpi GM, et al. Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility. Int J Androl. 2011; 34:600–13.
crossref
21. He L, Wang Y, Long Z, Jiang C. Clinical significance of IL-2, IL-10, and TNF-alpha in prostatic secretion of patients with chronic prostatitis. Urology. 2010; 75:654–7.
22. Orhan I, Onur R, Ilhan N, Ardicoglu A. Seminal plasma cytokine levels in the diagnosis of chronic pelvic pain syndrome. Int J Urol. 2001; 8:495–9.
crossref
23. Miller LJ, Fischer KA, Goralnick SJ, Litt M, Burleson JA, Albertsen P, et al. Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome. J Urol. 2002; 167:753–6.
crossref
24. Miller LJ, Fischer KA, Goralnick SJ, Litt M, Burleson JA, Albertsen P, et al. Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome. Urology. 2002; 59:603–8.
crossref
25. John H, Barghorn A, Funke G, Sulser T, Hailemariam S, Hauri D, et al. Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol. 2001; 39:72–8.
26. Eisenberg ER, Moldwin RM. Etiology: where does prostatitis stop and interstitial cystitis begin? World J Urol. 2003; 21:64–9.
crossref
27. Liu HT, Tyagi P, Chancellor MB, Kuo HC. Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment. BJU Int. 2009; 104:1476–81.
crossref
28. Watanabe T, Inoue M, Sasaki K, Araki M, Uehara S, Monden K, et al. Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment. BJU Int. 2011; 108:248–51.
crossref
29. Hellstrom WJ, Schmidt RA, Lue TF, Tanagho EA. Neuromuscular dysfunction in nonbacterial prostatitis. Urology. 1987; 30:183–8.
crossref
30. Kaplan SA, Santarosa RP, D'Alisera PM, Fay BJ, Ikeguchi EF, Hendricks J, et al. Pseudodyssynergia (contraction of the external sphincter during voiding) misdiagnosed as chronic nonbacterial prostatitis and the role of biofeedback as a therapeutic option. J Urol. 1997; 157:2234–7.
crossref
31. Kaplan SA, Te AE, Jacobs BZ. Urodynamic evidence of vesical neck obstruction in men with misdiagnosed chronic nonbacterial prostatitis and the therapeutic role of endoscopic incision of the bladder neck. J Urol. 1994; 152:2063–5.
crossref
32. Barbalias GA. Prostatodynia or painful male urethral syndrome? Urology. 1990; 36:146–53.
33. Barbalias GA, Nikiforidis G, Liatsikos EN. Alpha-blockers for the treatment of chronic prostatitis in combination with antibiotics. J Urol. 1998; 159:883–7.
crossref
34. Kirby RS, Lowe D, Bultitude MI, Shuttleworth KE. Intra-prostatic urinary reflux: an aetiological factor in abacterial prosta- titis. Br J Urol. 1982; 54:729–31.
35. Persson BE, Ronquist G. Evidence for a mechanistic association between nonbacterial prostatitis and levels of urate and creatinine in expressed prostatic secretion. J Urol. 1996; 155:958–60.
crossref
36. Ku JH, Kim SW, Paick JS. Quality of life and psychological factors in chronic prostatitis/chronic pelvic pain syndrome. Urology. 2005; 66:693–701.
crossref
37. Rodriguez MA, Afari N, Buchwald DS. National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain. Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol. 2009; 182:2123–31.
38. de la Rosette JJ, Ruijgrok MC, Jeuken JM, Karthaus HF, Debruyne FM. Personality variables involved in chronic prostatitis. Urology. 1993; 42:654–62.
crossref
39. Egan KJ, Krieger JN. Psychological problems in chronic prostatitis patients with pain. Clin J Pain. 1994; 10:218–26.
crossref
40. Ku JH, Jeon YS, Kim ME, Lee NK, Park YH. Psychological problems in young men with chronic prostatitis-like symptoms. Scand J Urol Nephrol. 2002; 36:296–301.
crossref
41. Clemens JQ, Brown SO, Calhoun EA. Mental health diagnoses in patients with interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome: a case/control study. J Urol. 2008; 180:1378–82.
crossref
42. Nickel JC, Tripp DA, Chuai S, Litwin MS, McNaughton-Collins M, Landis JR, et al. NIH-CPCRN Study Group. Psychosocial variables affect the quality of life of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome. BJU Int. 2008; 101:59–64.
crossref
43. Tripp DA, Nickel JC, Wang Y, Litwin MS, McNaughton-Collins M, Landis JR, et al. National Institutes of Health-Chronic Prostatitis Collaborative Research Network (NIH-CPCRN) Study Group. Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome. J Pain. 2006; 7:697–708.
crossref
44. Lan T, Wang Y, Chen Y, Qin W, Zhang J, Wang Z, et al. Influence of environmental factors on prevalence, symptoms, and pathologic process of chronic prostatitis/chronic pelvic pain syndrome in northwest China. Urology. 2011; 78:1142–9.
crossref
45. Hedelin H, Jonsson K. Chronic prostatitis/chronic pelvic pain syndrome: symptoms are aggravated by cold and become less distressing with age and time. Scand J Urol Nephrol. 2007; 41:516–20.
crossref
46. Hedelin H, Jonsson K, Lundh D. Pain associated with the chronic pelvic pain syndrome is strongly related to the ambient temperature. Scand J Urol Nephrol. 2012; 46:279–83.
crossref

Fig. 1.
Interplay of immunological, endocrine, neurological and psychological factors in development of CP/CPPS and proposed mechanisms. CP/CPPS: chronic prostatitis/chronic pelvic pain syndrome, NGF: nerve growth factor, IFN-γ: interferon-γ, IL: interleukin, TNF-α: tumor necrosis factor (adapted from Pontari and Ruggieri. J Urol 2008;179(5 Suppl):S61-7, with permission of Elsevier).6
kjutii-8-7f1.tif
Table 1.
Cytokines levels in → chronic prostatitis/chronic pelvic pain syndrome type IIIB vs. asymptomatic controls
Fluid IIIB vs. controls significant increased (p<0.05) References
IL-1β    
 Semen Yes Orhan et al.22
 EPS No John et al.25
IL-2    
 EPS No He et al.21
IL-6    
 Semen No Orhan et al.22
IL-8    
 Semen Yes Orhan et al.22
 EPS No Miller et al.23
IL-10    
 EPS Yes He et al.21
TNF-α    
 Semen Yes Orhan et al.22
 EPS Yes He et al.21
 EPS No John et al.25

IL: interleukin, EPS: expressed prostatic secretion, TNF-α: tumor necrosis factor (TNF)-α.

TOOLS
Similar articles