Journal List > Korean J Urogenit Tract Infect Inflamm > v.10(1) > 1059906

Kim, Kim, Lee, and Min: Effectiveness of Topical Ofloxacin Ointment for Genitourinary Post-Operative Patients with Urinary Catheterization

Abstract

Purpose

Catheter associated urinary tract infection and discomfort is common in patients with an indwelling urinary catheter. We investigated the effectiveness of prophylactic topical antibiotic ointment for genitourinary postoperative patients with a urinary catheter.

Materials and Methods

We investigated 112 inpatients between March 2013 and October 2013, who had an indwelling urinary catheter ≥24 hours after a genitourinary operation in our institution from medical records. Among 112 patients, 59 patients applied ofloxacin ointment to urethral meatus around the indwelling catheter twice a day (ointment group: 52.7%) and 53 patients did not (non-ointment group: 47.3%). All patients were examined by urine analysis and urine culture before the operation, urethral sweep culture after catheter removal, and severity of pain was recorded as visual analogue scale (VAS) score while having an indwelling urinary catheter.

Results

Mean duration of urinary catheter of both groups did not differ statistically (3.08±2.19 day, 2.91±2.25 day). Patients with pyuria detected at pre-operative urinalysis were 22.1% vs. 15.1%, pre-operative urine culture positive were 6.8% vs. 9.4%, urethra meatal culture positive after urethral catheter removal were 16.9% vs. 13.2%, respectively, and all results showed no significant differences between two groups. VAS scores of the ointment group (3.52±1.66) while having an indwelling urinary catheter were significantly lower than those of the non-ointment group (5.61±1.75) (p<0.001).

Conclusions

Application of topical antibiotic ointment for genitourinary postoperative patients with urinary catheter had no benefit in reducing growth of urethral microorganisms, but it may decrease pain from an indwelling urinary catheter.

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Fig. 1.
(A) Microorganisms that were cultured from urethra meatal swap culture of non-ointment group after urethral catheter removed. (B) Microorganisms that were cultured from urethra meatal swap culture of ointment group after urethral catheter removed.
kjutii-10-25f1.tif
Fig. 2.
(A) Average and standard deviation of visual analogue scale (VAS) scores between ointment group and non-ointment group during having a indwelling urinary catheter. (B) Average and standard deviation of VAS scores of male between ointment group and non-ointment group during having an indwelling urinary catheter. (C) Average and standard deviation of VAS scores of female between ointment group and non-ointment group during having an indwelling urinary catheter.
kjutii-10-25f2.tif
Table 1.
Baseline patients characteristics
Characteristic Ointment group (n=59) Non-ointment group (n=53) p-value
Sex (male:female) 47:12 43:10  
Age (y) 52.94±12.43 56.9±23.17 0.067
Catheter duration (day) 3.08±2.19 2.91±2.25 0.117
Pyuria (white blood cell >5, HPF) 13 (22.1) 8 (15.1) 0.092
Pre-operation urine culture 4 (6.8) 5 (9.4) 0.075
Urethra meatal culture positive (after urethral catheter removed) 10 (16.9) 7 (13.2) 0.078

Values are presented as number only, mean±standard deviation, or number (%).HPF: high power field.

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