Effect of Adiponectin and Resistin on Coronary Plaque Composition and Coronary Artery Remodeling of Target Lesion in Patients with Stable Angina

Jong-Youn Kim; Pil-Ki Min; Young-Won Yoon; Byoung Kwon Lee; Bum-Kee Hong; Hyuck Moon Kwon

doi:10.12997/jla.2012.1.2.69

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Kim, Min, Yoon, Lee, Hong, and Kwon: Effect of Adiponectin and Resistin on Coronary Plaque Composition and Coronary Artery Remodeling of Target Lesion in Patients with Stable Angina

Original Article

Journal of Lipid and Atherosclerosis 2012; 1(2): 69-78.

Published online: 31 December 2012

DOI: https://doi.org/10.12997/jla.2012.1.2.69

Effect of Adiponectin and Resistin on Coronary Plaque Composition and Coronary Artery Remodeling of Target Lesion in Patients with Stable Angina

Jong-Youn Kim¹, Pil-Ki Min^1,², Young-Won Yoon^1,², Byoung Kwon Lee¹, Bum-Kee Hong¹, Hyuck Moon Kwon¹

¹Cardiology Division, Heart Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

²Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea.

Corresponding Author: Pil-Ki Min, Cardiology Division, Heart Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, 211 Eunju-ro, Gangnam-gu, Seoul 135-720, Korea. Tel: +82-2-2019-3310, Fax: +82-2-3463-3882, cardioblues@yuhs.ac

Received 9 July 2012 Revised 23 July 2012 Accepted 27 July 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

The purpose of this study was to investigate the effect of adiponectin and resistin on coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and coronary artery remodeling of target lesion in patients with stable angina.

Methods

We prospectively enrolled 48 patients who underwent coronary angiography and VH IVUS for stable angina (27 men, 61±9 years of age). Preintervention grayscale and VH IVUS analysis was done across the target lesion. Planar VH IVUS analysis at the minimum luminal site and volumetric analysis over a 10-mm-long segment centered at the minimum luminal site were performed. The subjects were divided into 2 groups based on remodeling index (RI): positive remodeling (PR) defined as RI>1.0 and non-PR as RI≤1.0. Blood samples for analysis of adiponectin and resistin were obtained from the femoral artery before coronary angioplasty.

Results

Of the 48 patients enrolled, 23 (48%) had PR in their target lesion and 25 (52%) were non-PR group. Clinical and angiographic characteristics, VH IVUS parameters were not different between the PR and the non-PR groups. Adiponectin and resistin levels showed no significant correlations with coronary plaque composition evaluated with VH IVUS. Adiponectin showed no significant difference between the two groups. However, resistin showed trend toward higher level in non-PR group (4.17±2.18 ng/mL vs. 6.11±4.26 ng/mL, P=0.056) and a significant negative correlation with RI (r=-0.303, P=0.036).

Conclusion

We found a negative correlation between the resistin level and RI of a de-novo target lesion in patients with stable angina.

Keywords: Adiponectin, Resistin, Atherosclerotic plaque, Intravascular ultrasound, Arterial remodeling

Figures and Tables

Fig. 1

Level of (A) adiponectin, (B) resistin, and (C) hs-CRP in the PR and Non-PR groups. The line within the box denotes the median, and the box spans the interquartile range (25th to 75th percentiles). The whiskers extend from the 10th to 90th percentiles. PR, positive remodeling; hs-CRP, high sensitivity C-reactive protein.

Fig. 2

Correlation between coronary artery remodeling index and (A) resistin (r=-0.303, P=0.036, y=-0.017x+1.068) or (B) hs-CRP (r=0.327, P=0.035, y=0.027x+0.942). hs-CRP, high sensitivity C-reactive protein.

Fig. 3

Correlation between target lesion plaque burden and adiponectin (r=-0.316, P=0.029, y=-0.001x+61.538).

Table 1

Baseline clinical characteristics

PR: positive remodeling, BMI: body mass index, HDL: high-density lipoprotein, LDL: low-density lipoprotein, FBG: fasting blood glucose, HOMA: homeostatic model assessment, ACEI: angiotensin converting enzyme inhibitor, ARB: angiotensin receptor blocker

Table 2

Angiographic Characteristics

PR: positive remodeling, LAD: left anterior descending artery, LCX: left circumflex artery, RCA: right coronary artery, AHA: American Heart Association, ACC: American College of Cardiology

Table 3

Data for Intravascular Ultrasound and Virtual Histology

PR: positive remodeling, CSA: cross sectional area, EEM: external elastic membrane, P&M: plaque and media

Table 4

Correlations of adiponectin, resistin, and hs-CRP with coronary plaque composition determined by virtual histology intravascular ultrasound

hs-CRP: high sensitivity C-reactive protein, CSA: cross sectional area.

Notes

This study was supported by a faculty research grant of Yonsei University College of Medicine for 2007 (6-2007-0134).

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