Sensitization to component antigens in acute idiopathic urticaria in children

Young Jin Choi; Jung Min Yoon; Yeo Soon Chang; Jae-Won Oh

doi:10.4168/aard.2017.5.6.331

Journal List > Allergy Asthma Respir Dis > v.5(6) > 1059285

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Choi, Yoon, Chang, and Oh: Sensitization to component antigens in acute idiopathic urticaria in children

Original Article

Allergy, Asthma & Respiratory Disease 2017; 5(6): 331-335.

Published online: 30 November 2017

DOI: https://doi.org/10.4168/aard.2017.5.6.331

Sensitization to component antigens in acute idiopathic urticaria in children

Young Jin Choi¹, Jung Min Yoon², Yeo Soon Chang², Jae-Won Oh^1,²

¹Department of Pediatrics, Hanyang University Guri Hospital, Guri, Korea.

²Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.

Correspondence to: Jae-Won Oh. Department of Pediatrics, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 11923, Korea. Tel: +82-31-560-2254, Fax: +82-31-552-9493, jaewonoh@hanyang.ac.kr

Received 3 May 2017 Revised 26 September 2017 Accepted 27 September 2017

The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).

Abstract

Purpose

The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD).

Methods

We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP).

Results

Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10–40.59), 6 to rConr a 1 for hazelnut (1.53–11.97), 4 to rPru p 1 for peach (1.32–11.83). 6 to rAra h 8 for peanut (1.20–8.12), 6 to nAct d 8 for kiwi (0.85–3.32), 4 to rBet v 1 for birch (2.49–54.28), and 3 to rAln g 1 for alder (2.32–5.74). Six children were positive to nPru p 3 for peach (1.45–18.77), 4 to rCor a 8 for hazelnut (2.56–9.19), 2 to nArt v 3 for mugwort (3.40–7.42), and 3 to rBet v2 to profilin of birch (2.56–17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3).

Conclusion

IgE sensitization to PR-10 or nsLTP may be allergen components for AIU in childhood.

Keywords: Urticaria, Allergen, Diagnosis

Figures and Tables

Table 1

The results of 22 children with component-resolved diagnostics positive in 74 acute idiopathic urticarias

Subjects		PR-10								nsLTP			Profilins
Subjects		Birch	Alder	Hazel nut	Apple	Peach	Soybean	Peanut	Kiwi	Peach	Hazelnut	Mugwort	Birch
Sex	Age (yr)	rBet v 1	rAln g 1	rCor a 1.0401	rMal d 1	rPru p 1	rGly m 4	rAra h 8	nAct d 8	nPru p 3	rCor a 8	nArt v 3	rBet v 2
F	5	0.00	0.00	0.00	0.00	3.50	0.00	0.00	0.00	0.00	0.00	0.00	0.00
F	4	0.00	0.00	2.10	2.70	0.00	0.00	1.20	3.22	0.00	2.56	0.00	0.00
F	3	0.00	0.00	0.00	0.00	0.00	1.79	0.00	0.00	4.70	0.00	0.00	0.00
M	3	0.00	0.00	0.00	1.10	2.90	0.00	0.00	0.00	0.00	0.00	0.00	0.00
F	6	0.00	0.00	3.77	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
F	5	0.00	0.00	0.00	3.45	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
F	12	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.45	0.00	0.00	0.00
M	13	0.00	0.00	0.00	0.00	0.00	4.26	0.00	0.00	0.00	0.00	0.00	0.00
M	10	6.83	0.00	0.00	3.34	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
M	7	0.00	0.00	1.53	0.00	0.00	0.00	0.00	0.00	18.77	9.19	7.42	17.46
F	9	0.00	0.00	0.00	0.00	0.00	0.00	2.78	1.56	4.60	0.00	0.00	0.00
F	7	0.00	4.23	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
F	2	0.00	0.00	0.00	4.83	0.00	0.00	0.00	3.32	0.00	0.00	0.00	0.00
M	11	0.00	0.00	0.00	0.00	11.83	1.05	0.76	0.85	1.45	0.00	0.00	0.00
M	13	0.00	0.00	0.00	3.32	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
M	10	2.49	0.00	3.23	0.00	0.00	0.00	0.00	1.26	0.00	3.23	0.00	0.00
F	8	0.00	0.00	0.00	8.67	4.34	0.00	0.00	0.00	3.55	0.00	0.00	0.00
F	7	4.82	2.32	5.20	0.00	0.00	0.00	0.00	3.26	0.00	0.00	3.40	10.29
M	13	0.00	0.00	0.00	40.59	8.89	0.00	8.12	0.00	0.00	0.00	0.00	0.00
M	6	0.00	0.00	0.00	12.34	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
M	14	54.28	5.74	11.97	2.20	1.32	0.00	0.00	0.00	2.27	3.44	0.00	2.56
F	2	0.00	0.00	0.00	0.00	0.00	2.56	0.00	0.00	0.00	0.00	0.00	0.00

PR-10, pathogenesis-related protein family number 10; nsLTP, nonspecific lipid transfer proteins.

Table 2

The positive results of PR-10 in children with acute idiopathic urticaria

Component	No. of subject (%)	Value range
rMal d 1 for apple	10 (45.5)	1.10–40.59
rCor a 1 for hazelnut	6 (27.3)	1.53–11.97
rAra h 8 for peanut	6 (27.3)	1.20–8.12
nAct d 8 for kiwi	6 (27.3)	0.85–3.32
rPru p 1 for peach	4 (18.2)	1.32–11.83
rGly m 4 for soybean	4 (18.2)	1.05–4.26
rBet v 1 for birch	4 (18.2)	2.49–54.28
rAln g 1 for alder	3 (13.6)	2.32–5.74

PR-10, pathogenesis-related protein family number 10.

Table 3

The positive results of nsLTP and profilin in children with acute idiopathic urticaria

Component	No. of subject (%)	Value range
nsLTP
nPru p 3 for peach	7 (31.8)	1.45–18.77
rCor a 8 for hazelnut	4 (18.2)	2.56–9.19
nArt v 3 for mugwort	2 (9.1)	3.40–7.42
Profilin
rBet v 2 for birch	3 (13.6)	2.56–17.46

nsLTP, nonspecific lipid transfer proteins.

Table 4

Multiple positive results of PR-10, profilin, and nsLTP in children with acute idiopathic urticaria

Source	Component	No. of subject (%)
Hazelnut	PR-10 (rCor a 1) and nsLTP (rCor a 1)	4 (18.2)
Peach	PR-10 (rPru p 1) and nsLTP (nPru p 3)	3 (13.6)
Birch	PR-10 (rBet v 1) and profilin (rBet v 2)	2 (9.1)

PR-10, pathogenesis-related protein family number 10.

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ORCID iDs: Jae-Won Oh
https://orcid.org/0000-0003-2714-0065
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