Abstract
Purpose
Exhaled breath temperature (EBT) has been suggested as a noninvasive marker of airway inflammation in asthma. The aim of this study was to determine its clinical implication in children with asthma.
Methods
A total of 233 children were enrolled in this study. Among them, 116 were asthmatic children and 117 were healthy children. Spirometry, bronchodilator response (BDR) test, methacholine challenge test, and skin prick test were performed. EBT, fractional exhaled nitric oxide (FeNO), blood eosinophils, and total IgE levels were measured. EBT was measured by using X-halo.
Results
EBT was significantly higher in the asthma group than in the control group (median [interquartile range], 32.1° C [30.0° C– 33.9° C] vs. 29.7° C [29.0° C–31.3° C], P<0.001). EBT was significantly higher in poorly or partly controlled asthmatic children than well-controlled asthmatic children (33.5° C [31.0° C–34.4° C] vs. 30.3° C [29.3° C–32.9° C], P<0.0001). Among total subjects, EBT was significantly higher in the atopic group than in the nonatopic group (32.4° C [30.3° C–34.0° C] vs. 29.8° C [29.0° C–30.3° C], P<0.001). There were neither significant associations between EBT and BDR (r=0.109, P=0.241) nor between EBT and PC20 (provocation concentration causing a 20% fall in FEV1) in total subjects (r=0.127, P=0.316). EBT did not show any association with FeNO (r=0.353, P=0.071).
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