Human microbiome studies in Korea

Sungmi Choi; Sang-Heon Cho; Hana Yi

doi:10.4168/aard.2016.4.5.311

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Choi, Cho, and Yi: Human microbiome studies in Korea

Review

Allergy, Asthma & Respiratory Disease 2016; 4(5): 311-320.

Published online: 30 September 2016

DOI: https://doi.org/10.4168/aard.2016.4.5.311

Human microbiome studies in Korea

Sungmi Choi¹, Sang-Heon Cho², Hana Yi^1,³

¹Department of Public Health Sciences, Graduate School, Korea University, Seoul, Korea.

²Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

³School of Biosystem and Biomedical Science, Korea University, Seoul, Korea.

Correspondence to: Hana Yi. School of Biosystem and Biomedical Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea. Tel: +82-2-3290-5644, Fax: +82-2-940-2849, hanayi@korea.ac.kr

Received 30 March 2016 Revised 29 April 2016 Accepted 16 May 2016

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).

Abstract

During the second half of the 2000s, the significant impact of human microbiome on human diseases and health conditions was found. Since the Human Microbiome Project, many microbiome studies have been reported in domestic and international references. Gastrointestinal tract microbiome has been most investigated so far, and the association with illness has been demonstrated in many diseases. Recently, the range of study was extended to multiple human organs, such as the respiratory tract, skin, and urogenital tract. Given the scale and speed of research and development in recent years, the role of microbiome in many diseases would be established before long. In this review, we aimed to summarize the current status of microbiome studies in Korea and foreign countries with an emphasis on respiratory tract microbiome. The main concept and analytical methods for microbiome research, associations of microbiome and diseases, and research projects on Korean microbiome are reviewed.

Keywords: Microbiota, Gastrointestinal microbiome, Metagenomics, Respiratory airflow, Korea

Figures and Tables

Fig. 1

Number of the publications by National Institutes of Health (NIH) Human Microbiome Project (HMP), USA. Distribution of the publications depending on calendar year (A), and depending on associated organs or diseases (B). Data from the NIH HMP website (http://hmpdacc.org).

Fig. 2

Count of microbiome research funding and publications in Korea.

Table 1

Major international microbiome projects

Country	Project title	Duration	Objective
International	International Human Microbiome Consortium (IHMC)	2010–	Set principles and policies to study microbiome. Mediate projects to generate a comprehensive data resource.
EU	Metagenomics of the Human Intestinal Tract (MetaHIT)	2008–2011	Construct large catalog of intestinal microbiome and genes of IBD and obesity.
EU	International Human Microbiome Standards (IHMS)	2011–2015	Establish a standard protocol for human microbiome studies.
USA	NIH Human Microbiome Project (HMP)	2008–2015	Generate resources of the human microbiome. Diagnosis and treatment through a correlation between diseases and microbiome.
	Home Microbiome Project	2012–	Analyze bacterial community in living space.
	Data Analysis and Coordination Center (DACC)	2008–2013	Assist in standard of data pipeline.
	Hospital Microbiome Project	2012–2014	Analyze bacterial community in hospital, and find correlation between the bacteria and patient.
	Microbiome Quality Control Project (MBQC)	2013–	Establish analytic pipeline of human fecal microbiome.
	American Gut Project	2013–	Study of bacterial diversity of the public and construct data resource.
Japan	Japanese Consortium for Human Microbiome (JCHM)	2014–	Study of Japanese specific intestinal microbiome and disease biomarker.
Canada	Canadian Microbiome Initiative (CMI)	2009–	Support seven research teams to conduct a prospective study of diseases by modeling and mapping microbial diversity.
France	MicroObes	2008–2010	Research on obesity and human intestinal microbiome.
France	MetaGenoPolis (MGP)	2012–2019	Find the correlation of non-infectious diseases and intestinal microbiome.
Korea	Korean Microbiome Diversity Using Korean Twin Cohort Project	2010–2015	Study on human diseases related microbiome using twin cohort and characterize Korean specific microbiome.
Australia	The Australian Jumpstart Human Microbiome Project	2009	Analyze metagenome of intestinal microbes and Australian specific microbiome.

Notes

This research was supported by a fund (code: 2015ER660300) by Research of Korea Centers for Disease Control and Prevention.

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Supplementary Material

Supplementary Table 1

Publications of Korean microbiome research

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ORCID iDs: Hana Yi
https://orcid.org/http://orcid.org/0000-0002-4910-122X
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