Air pollution and childhood allergic disease

Young Yoo

doi:10.4168/aard.2016.4.4.248

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Yoo: Air pollution and childhood allergic disease

Review

Allergy, Asthma & Respiratory Disease 2016; 4(4): 248-256.

Published online: 31 July 2016

DOI: https://doi.org/10.4168/aard.2016.4.4.248

Air pollution and childhood allergic disease

Young Yoo^1,^2,³

¹Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.

²Environmental Health Center, Korea University Anam Hospital, Seoul, Korea.

³Allergy Immunology Center, Korea University, Seoul, Korea.

Correspondence to: Young Yoo. Department of Pediatrics, Korea University Anam Hospital, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea. Tel: +82-2-920-5090, Fax: +82-2-922-7476, yoolina@korea.ac.kr

Received 13 February 2016 Revised 18 April 2016 Accepted 19 April 2016

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).

Abstract

Epidemiological studies suggest that there is a strong relationship between air pollution and childhood allergic disease. This review will summarize the association between exposure to air pollutants and subsequent development of asthma, allergies, and sensitization. Air pollutants probably induce oxidative stress, epigenetic change, and altered microRNA expression in the airway and skin, leading to immune dysregulation. This review considers acute and chronic effects of air pollution on the development and aggravation of allergic disease; the adverse health effect of air pollution on susceptible population, particular time period, and coexposure to allergens; and potential mechanisms involving development of allergic disease by exposure to air pollutants.

Keywords: Air pollution, Allergy, Environment

Figures and Tables

Fig. 1

Exposure to air pollutants in susceptible population can elicit epithlial barrier dysfunction, oxidative stress, epigenetic change and immune imbalance which subsequently increases allergic disease morbidity. PM, particulate matter; DEP, diesel exhaust particle; PAHs, polycyclic aromatic hydrocarbons; ETS, environmental tobacco smoke; HDM, house dust mite.

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ORCID iDs: Young Yoo
https://orcid.org/http://orcid.org/0000-0003-3354-6969
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