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Heirim Lee, Min-Sun Kim, Hea-Kyoung Yang, Minji Kim, Ji Young Lee, Jong-Min Kim*, Ji-Man Kang, Yae-Jean Kim, Kangmo Ahn, Jihyun Kim
Abstract
Hypersensitivity reactions to antituberculosis medicine are obstacles to the treatment of tuberculosis. However, rapid drug desensitization can secure successful treatment with essential antituberculosis medicines in pediatric patients. A 17-year-old boy with active pulmonary tuberculosis complained of generalized erythematous rashes, pruritus on the 11th day of tuberculosis treatment. He was diagnosed with hypersensitivity reactions to isoniazid and rifampin by the oral provocation test. After desensitization, the patient continued to take antituberculosis treatment with isoniazid, rifampin, pyrazinamide, and ethambutol. We report here a case of successful desensitization in an adolescent with hypersensitivity to isoniazid and rifampin.
Figures and Tables
Table 1
The result of skin test of rifampin and isoniazid
Table 2
Oral desensitization protocol for rifampin
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