Raw shiitake-induced systemic allergic contact dermatitis

Kyu-Man Cho; Jae-Uoong Shim; Ji-Eun Yu; Young-Il Koh

doi:10.4168/aard.2015.3.6.452

Journal List > Allergy Asthma Respir Dis > v.3(6) > 1059147

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Cho, Shim, Yu, and Koh: Raw shiitake-induced systemic allergic contact dermatitis

Case Report

Allergy, Asthma & Respiratory Disease 2015; 3(6): 452-455.

Published online: 30 November 2015

DOI: https://doi.org/10.4168/aard.2015.3.6.452

Raw shiitake-induced systemic allergic contact dermatitis

Kyu-Man Cho, Jae-Uoong Shim, Ji-Eun Yu, Young-Il Koh

Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Correspondence to: Young-Il Koh. Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Korea. Tel: +82-62-220-6580, Fax: +82-62-225-8578, yikoh@chonnam.ac.kr

Received 4 July 2015 Revised 14 September 2015 Accepted 14 September 2015

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

It has been reported that ingestion of raw or undercooked shiitake mushrooms is associated with various adverse food reactions. A 58-year-old man presented with pruritic and maculopapular rashes on the trunk and extremities starting 1 day after ingestion of partially uncooked shiitake mushrooms. A probable diagnosis of systemic allergic contact dermatitis was made. Raw and cooked shiitake mushroom-derived allergen extracts were prepared, and patch and intradermal tests with delayed readings were performed. The case showed positive intradermal test results with delayed readings to the raw, but not cooked, extracts. The case suggests that ingestion of uncooked shiitake mushrooms may induce systemic allergic contact dermatitis through type IV hypersensitivity reaction.

Keywords: Contact dermatitis, Shiitake mushroom, Patch test, Intradermal test

Figures and Tables

Fig. 1

Maculopapular rashes on skin on admission.

Fig. 2

Results of intradermal test with delayed readings. Intradermal test with raw (fresh) and boiled shiitake allergen extracts was done and was read at 48 hours. The extracts were diluted to 1:100 (0.05 mg/mL), 1:10 (0.5 mg/mL), and 1:1 (5 mg/mL).

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ORCID iDs: Young-Il Koh
https://orcid.org/http://orcid.org/0000-0002-5100-9473
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