Journal List > Allergy Asthma Respir Dis > v.3(6) > 1059146

Chun, Choi, Kim, Kim, Kim, Choi, and Kang: Successful administration of iodinated contrast media in a patient with anaphylaxis to multiple contrast media


Although hypersensitivity reactions to iodinated contrast media (ICM) are uncommon, their clinical impacts are considerable because of their wide use and potential fatality. The best way to prevent ICM-induced hypersensitivity is to avoid re-exposure to the ICM. However, ICM use is inevitable in the evaluation of many diseases. A 64-year-old male with renal cell carcinoma presented with anaphylaxis after computed tomography (CT) using iohexol. Intradermal test results were positive to iohexol, iomeprol, and ioversol. The following 3 CT scans using the test-negative agents iopromide, iopamidol, and iobitridol still provoked hypersensitivity reactions despite premedication using intravenous antihistamine and corticosteroid. For the next step, iodixanol, a nonionic iso-osmolar dimer, was tested by intravenous graded challenges in addition to the intradermal skin test, which and was confirmed to be negative. The patient underwent CT scan using iodixanol after premedication with chlorpheniramine 4 mg and methylprednisolone 40 mg, and hypersensitivity reactions did not recur. We report a case of a patient showing hyper reactivity to multiple ICMs despite negative intradermal skin tests, who eventually underwent successful enhanced CT scans after choosing ICM by the graded challenge test.

Figures and Tables

Table 1

Individual iodinated contrast media and premedications at the time of hypersensitivity reaction

No. Contrast Premedication Adverse reaction Severity Treatment
1-18 N/A None None - -
19 Ultravist370 (Iopromide) None Diffuse urticaria, angioedema Moderate Antihistamine
20 Omnihexol350 (Iohexol) AH None - -
21 Omnihexol350 (Iohexol) AH Itching, erythema Mild Observation
22 Omnihexol350 (Iohexol) AH None - -
23 Omnihexol350 (Iohexol) AH Hypotension, loss of consciousness Severe N/S hydration, epinephrine 0.5 mg/mL IM
24 Pamiray300 (Iopamidol) AH, S Diffuse erythema Moderate Observation
25 Xenetix350 (Iobitridol) AH, S Hypotension Severe N/S hydration, epinephrine 0.5 mg/mL IM
26-30 Visipaque320 (Iodixanol) AH, S None - -

NA, not available; AH, chlorpheniramine 4 mg; S, methylprednisolone; N/S, 0.9% normal saline; IM, intramuscular.


This research was supported by a grant from Ministry of Food and Drug Safety to operation of the regional pharmacovigilance center in 2015.


1. Lee SY, Lim KW, Chang YS. Radiocontrast media hypersensitivity in the Asia Pacific region. Asia Pac Allergy. 2014; 4:119–125.
2. Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K. Adverse reactions to ionic and nonionic contrast media: a report from the Japanese Committee on the Safety of Contrast Media. Radiology. 1990; 175:621–628.
3. Brockow K, Romano A, Aberer W, Bircher AJ, Barbaud A, Bonadonna P, et al. Skin testing in patients with hypersensitivity reactions to iodinated contrast media: a European multicenter study. Allergy. 2009; 64:234–241.
4. Brockow K, Ring J. Classification and pathophysiology of radiocontrast media hypersensitivity. Chem Immunol Allergy. 2010; 95:157–169.
5. Yoon SH, Lee SY, Kang HR, Kim JY, Hahn S, Park CM, et al. Skin tests in patients with hypersensitivity reaction to iodinated contrast media: a meta-analysis. Allergy. 2015; 70:625–637.
6. Salas M, Gomez F, Fernandez TD, Dona I, Aranda A, Ariza A, et al. Diagnosis of immediate hypersensitivity reactions to radiocontrast media. Allergy. 2013; 68:1203–1206.