Medical treatment according to phenotypes of chronic rhinosinusitis

Seung-No Hong; Dae Woo Kim

doi:10.4168/aard.2015.3.3.167

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Hong and Kim: Medical treatment according to phenotypes of chronic rhinosinusitis

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Allergy, Asthma & Respiratory Disease 2015; 3(3): 167-172.

Published online: 29 May 2015

DOI: https://doi.org/10.4168/aard.2015.3.3.167

Medical treatment according to phenotypes of chronic rhinosinusitis

Seung-No Hong, Dae Woo Kim

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Correspondence to: Dae Woo Kim. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 156-707, Korea. Tel: +82-2-870-2446, Fax: +82-2-831-0714, kicubi@daum.net

Received 6 November 2014 Revised 6 February 2015 Accepted 17 February 2015

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Chronic rhinosinusitis is generally divided into 2 types. One is chronic rhinosinusitis with nasal polyps and the other is chronic rhinosinusitis without nasal polyps. However, this classification has the drawbacks no consideration of various immunologic characters of chronic rhinosinusitis and too simple grouping. To compensate for these drawbacks, 1 recent classification has utilized histologic and immunologic parameters to subdivide chronic rhinosinusitis with nasal polyps into that with eosinophilic polyps and that with noneosinophilic nasal polyps. Moreover, phenotyping of chronic rhinosinusitis by using various clinical parameters such as biopsy, computed tomography, and endoscopic findings is very important for the appropriate medical treatment. In this review, before discussing the overall medical treatment of chronic rhinosinusitis, we describe not only clinical characters of chronic rhinosinusitis without nasal polyps but also the immunologic and histologic differentiation of chronic rhinosinusitis cases with eosinophilic and noneosinophilic nasal polyps closely related to the phenotype of chronic rhinosinusitis.

Keywords: Sinusitis, Nasal polyps, Eosinophils, Phenotype, Individualized medicine

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